Timothy Yu, M.D., Ph.D.

Associate Professor, Harvard Medical School

SFARI Investigator Website

Timothy Yu is a neurologist and genomics researcher at Boston Children’s Hospital and Harvard Medical School. His research group applies advanced genomic methods to advance our understanding of the genetic and neurobiological underpinnings of neurodevelopmental disorders, at the bench and in the clinic. He received his B.A. in biochemistry and molecular biology from Harvard College and M.D. and Ph.D. in neuroscience from the University of California, San Francisco, completed neurology residency training at Massachusetts General Hospital (MGH) and Brigham and Women’s Hospital and did a neurodevelopmental disorders fellowship at Boston Children’s Hospital and the MGH Lurie Center.

Yu’s laboratory is based in the Division of Genetics and Genomics at Boston Children’s Hospital. He holds academic appointments at Harvard Medical School and the Broad Institute of the Massachusetts Institute of Technology (MIT) and Harvard and is co-founder of Claritas Genomics, a genomic medicine company for children with rare disease.

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Funded Projects

SFARI Funded Publications

Disruption of RFX family transcription factors causes autism, attention-deficit/hyperactivity disorder, intellectual disability, and dysregulated behavior. Harris H.K., Nakayama T., Lai J., Zhao B., Argyrou N., Gubbels C.S., Soucy A., Genetti C.A., Suslovitch V., Rodan L.H., Tiller G.E., Lesca G., Gripp K.W., Asadollahi R., Hamosh A., Applegate C.D., Turnpenny P.D., Simon M.E.H., Volker-Touw C.M.L., van Gassen K.L.I., van Binsbergen E., Pfundt R., Gardeitchik T., de Vries B.B.A., Immken L.L., Buchanan C., Willing M., Toler T.L., Fassi E., Baker L., Vansenne F., Wang X., Ambrus J.L., Jr., Fannemel M., Posey J.E., Agolini E., Novelli A., Rauch A., Boonsawat P., Fagerberg C.R., Larsen M.J., Kibaek M., Labalme A., Poisson A., Payne K.K., Walsh L.E., Aldinger K.A., Balciuniene J., Skraban C., Gray C., Murrell J., Bupp C.P., Pascolini G., Grammatico P., Broly M., Küry S., Nizon M., Rasool I.G., Zahoor M.Y., Kraus C., Reis A., Iqbal M., Uguen K., Audebert-Bellanger S., Ferec C., Redon S., Baker J., Wu Y., Zampino G., Syrbe S., Brosse I., Abou Jamra R., Dobyns W.B., Cohen L.L., Blomhoff A., Mignot C., Keren B., Courtin T., Agrawal P.B., Beggs A., Yu T.
Insights into autism spectrum disorder genomic architecture and biology from 71 risk loci. Sanders S., He X., Willsey A. J., Ercan-Sencicek A.G., Samocha K.E., Çiçek A. E., Murtha M.T., Bal V.H., Bishop S., Dong S., Goldberg A.P., Jinlu C., Keaney J.F. 3rd, Klei L., Mandell J.D., Moreno-De-Luca D., Poultney C.S., Robinson E., Smith L., Solli-Nowlan T., Su M.Y., Teran N.A., Walker M.F., Werling D., Beaudet A., Cantor R.M., Fombonne E., Geschwind D., Grice D.E., Lord C., Lowe J.K., Mane S.M., Martin D.M., Morrow E., Talkowski M., Sutcliffe J., Walsh C., Yu T., Autism Sequencing Consortium, Ledbetter D., Martin C. L., Cook E. H., Buxbaum J., Daly M., Devlin B., Roeder K., State M.
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