SFARI Gene

3d render of a DNA spirals

SFARI Gene is an evolving online database designed to permit quick entrée into the genetics of autism, and to help researchers track the ever-expanding genetic risk factors that emerge in the literature1,2.

The site provides several ways of accessing data on autism candidate genes:

  • Human Gene Module lists 1,007 genes implicated in autism, with annotations and links to published papers.
  • Animal Model Module lists 1,083 mouse lines and 240 rat lines, including genetic models, inbred lines, models induced by biological or chemical agents and rescue lines. Drosophila and zebrafish models have recently been added to the database, including 55 genes for Drosophila and 24 genes for zebrafish.
  • Protein Interaction Network (PIN) Module curates all protein-protein and protein-nucleic acid interactions reported in the literature.
  • Copy Number Variant (CNV) Module provides exhaustive detail on all CNVs reported in individuals with autism.
  • Gene Scoring Module offers critical evaluation of the strength of the evidence for each gene’s association with autism. These gene scores are increasingly being used in the published literature3-11. 84 high-ranking candidate risk genes (see Table 1) have so far been identified.

 
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Table 1. Highest ranking candidate autism risk genes (ranked according to SFARI Gene).

 

References:

  1. Abrahams B.S. et al. Mol. Autism 4, 36 (2013) PubMed
  2. Banerjee-Basu S. and A. Packer Dis. Model Mech. 3, 133-135 (2010) PubMed
  3. Wang T. et al. Hum. Mol. Genet. 21, 5500-5510 (2012) PubMed
  4. Parikshak N.N. et al. Cell 155, 1008-1021 (2013) PubMed
  5. Jacquemont S. et al. Am. J. Hum. Genet. 94, 415-425 (2014) PubMed
  6. Toma C. et al. Mol. Psych. 19, 784-790 (2014) PubMed
  7. Sugathan A. et al. Proc. Natl. Acad. Sci. USA 111, E4468-4477 (2014) PubMed
  8. Griswold A.J. et al. Mol. Autism 6, 43 (2015) PubMed
  9. Strong E. et al. Am. J. Hum. Genet. 97, 216-227 (2015) PubMed
  10. Wilkinson B. et al. Transl. Psychiatry 5, e568 (2015) PubMed
  11. Yao P. et al. Nat. Neurosci. 18, 1168-1174 (2015) PubMed
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