SFARI Gene

3d render of a DNA spirals

SFARI Gene is an evolving online database designed to permit quick entrée into the genetics of autism, and to help researchers track the ever-expanding genetic risk factors that emerge in the literature1,2.

The site provides several ways of accessing data on autism candidate genes:

  • Human Gene Module lists 881 genes implicated in autism, with annotations and links to published papers.
  • Animal Model Module lists 1,043 mouse lines and 223 rat lines, including genetic models, inbred lines, models induced by biological or chemical agents and rescue lines.
  • Protein Interaction (PIN) Module curates all protein-protein and protein-nucleic acid interactions reported in the literature.
  • Copy Number Variant (CNV) Module provides exhaustive detail on all CNVs reported in individuals with autism.
  • Gene Scoring Module offers critical evaluation of the strength of the evidence for each gene’s association with autism. These gene scores are increasingly being used in the published literature3-11. 65 high-ranking candidate risk genes (see Table 1) have so far been identified.

Go to SFARI Gene »

 

Table 1. Highest ranking candidate autism risk genes (ranked according to SFARI Gene).

References:

  1. Abrahams B.S. et al. Mol. Autism 4, 36 (2013) PubMed
  2. Banerjee-Basu S. and A. Packer Dis. Model Mech. 3, 133-135 (2010) PubMed
  3. Wang T. et al. Hum. Mol. Genet. 21, 5500-5510 (2012) PubMed
  4. Parikshak N.N. et al. Cell 155, 1008-1021 (2013) PubMed
  5. Jacquemont S. et al. Am. J. Hum. Genet. 94, 415-425 (2014) PubMed
  6. Toma C. et al. Mol. Psych. 19, 784-790 (2014) PubMed
  7. Sugathan A. et al. Proc. Natl. Acad. Sci. USA 111, E4468-4477 (2014) PubMed
  8. Griswold A.J. et al. Mol. Autism 6, 43 (2015) PubMed
  9. Strong E. et al. Am. J. Hum. Genet. 97, 216-227 (2015) PubMed
  10. Wilkinson B. et al. Transl. Psychiatry 5, e568 (2015) PubMed
  11. Yao P. et al. Nat. Neurosci. 18, 1168-1174 (2015) PubMed
Subscribe to our newsletter and receive SFARI funding announcements and news