Events

Upcoming Lectures

There are currently no upcoming lectures,
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Past Lectures

Thinking differently about neurodevelopmental disorders and autism: Lumping vs. splitting

Evdokia Anagnostou, M.D.Assistant Director, Bloorview Research Institute
Child Neurologist and Senior Clinician Scientist, Holland Bloorview Kids Rehabilitation Hospital
Associate Professor, Department of Pediatrics, University of Toronto

On September 26, 2018, Evdokia Anagnostou will discuss the challenge of rethinking classification systems and diagnostic labels for autism and related neurodevelopmental disorders in light of recent findings from research and clinical studies.

Autism genetics: Where have we been and where are we going?

Matthew State, M.D., Ph.D.Oberndorf Family Distinguished Professor and Chair, University of California, San Francisco

On April 10, 2018, Matthew State reviewed the progress that has been made in autism genetics over the past 10 years and the role that the Simons Simplex Collection (SSC) played in this (r)evolution. He also addressed the potential contribution of ongoing genomic studies including whole-genome sequencing as well as the challenges and opportunities of leveraging the genetic findings to identify pathophysiological mechanisms.

On the road to precision health: Brain-based biomarkers in autism spectrum disorder

Shafali Spurling Jeste, M.D.Associate Professor in Psychiatry, Neurology and Pediatrics, University of California, Los Angeles
Director, Developmental Neurophysiology Lab, Center for Autism Research and Treatment, University of California, Los Angeles

On 7 February 2018, Shafali Spurling Jeste provided a topical overview of the current state of research in autism biomarkers. She shared data from studies of autism biomarkers in three key areas: early risk prediction (studies of high-risk infants), heterogeneity within the autism spectrum and genetically defined subgroups within autism. Finally, she discussed the challenges around clinical trial design and development and considered how more objective measures of brain function can improve clinical trials.

Arousal, emotion regulation and challenging behaviors: Insights from the Autism Inpatient Collection

Matthew Siegel, M.D.Associate Professor of Psychiatry and Pediatrics, Tufts University
Vice President, Medical Affairs, Developmental Disorders Service, Maine Behavioral Healthcare

On 24 January 2018, Matthew Siegel drew upon a new resource, the Autism Inpatient Collection data set, to offer preliminary insights into the relationships between physiologic arousal, emotion dysregulation and the occurrence of challenging behaviors. Such behaviors may represent an attempt to modulate physiologic arousal in minimally verbal individuals with autism spectrum disorders.

Autism genetics: Searching for coherence

Daniel Geschwind, M.D., Ph.D.Professor, University of California, Los Angeles

On 28 November 2017, Daniel Geschwind discussed his group’s use of RNA sequencing, chromatin structure and gene networks to help develop an understanding of potential convergent mechanisms in autism spectrum disorders.

Understanding autism and other neurodevelopmental disorders: From the embryo to brain organoids

Paola Arlotta, Ph.D.Professor, Harvard University

On 1 November 2017, Paola Arlotta focused on the cerebral cortex and presented the challenges and opportunities of modeling human brain development using pluripotent stem cells within 3D human brain organoids. Building on developmental work in mice, such organoids promise a better understanding of complex neurodevelopmental conditions such as autism spectrum disorder.

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