James Gusella and Michael Talkowski develop a CRISPR/CAS9 genomic method to generate microdeletions and microduplications in human iPSCs that mirror human CNV genetics.
The Autism Inpatient Collection, directed by Matthew Siegel, enrolls individuals severely affected by autism, facilitating assessment of this under-represented group.
Evan Eichler compares whole-genome and whole exome sequencing data of ASD indivduals and finds an enrichment of variants in putative noncoding regulatory elements in ASD.
Sandeep Robert Datta describes a combined 3D computer vision/machine-learning method that identifies behavioral modules expressed by freely behaving mice.
Irving Reti assesses, in two ASD mouse models, the utility of targeted, subthalamic nucleus, deep brain stimulation to treat severe forms of self-injurious behavior.