Research Highlights

Highlights of SFARI-funded papers, selected by the SFARI science team.

Targeting somatosensory over-reactivity in mouse models of ASD

David Ginty and colleagues have identified mechanisms through which peripheral loss of ASD-associated genes affect behaviors in mice and identify a potential peripherally restricted therapy to treat tactile over-reactivity and select ASD-related behaviors.

September 30, 2019

Predicting aggression with wearable biosensors

Matthew Goodwin, Matthew Siegel and colleagues found that data from a wearable biosensor can be used to accurately predict aggressive behavior up to one minute before it occurs.

September 30, 2019

Aberrant neocortical connectivity in Shank3 mutant mice Alessandro Gozzi and colleagues found that Shank3-deficient mice have disrupted frontocortical functional connectivity, which is associated with impaired communication and social behaviors.

Unexpected synaptic role for the autism risk gene Scn2a Kevin Bender, Stephan Sanders and colleagues show that there is an unexpectedly critical role for the autism risk gene Scn2a, which encodes the sodium channel NaV1.2, in postnatal dendritic excitability and synaptic function in mice.

A pipeline for functional assessment of autism-associated missense mutations in C. elegans Paul Sternberg and colleagues establish an initial pipeline in C. elegans to screen autism-associated missense mutations for functional effects.

Distinct patterns of connectivity underlie differences in sensory responsiveness in autism Susan Bookheimer and colleagues show that the degree of sensory overresponsivity in individuals with autism may be driven by distinct patterns of connectivity between the prefrontal cortex and amygdala.

A mouse model of 22q11.2 deletion syndrome shows reduced long-range connectivity and dysfunctional mitochondria Anthony-Samuel LaMantia, Thomas Maynard and colleagues show that a mouse model of 22q11.2 deletion syndrome has fewer long-distance cortico-cortical connections, which is caused in part by mitochondrial dysfunction.

Two studies using SPARK’s research matching program attest to its effectiveness for rapid and large-scale testing of research questions Two studies from Brigitta Monz, Richard Houghton and colleagues provide examples of the effectiveness of SPARK’s research match program to rapidly recruit thousands of individuals for the large-scale testing of research questions.

Brief treatment with statin yields long-term benefit in rat model of fragile X syndrome Peter Kind and colleagues show that brief treatment with lovastatin results in sustained correction of physiological and behavioral deficits in a rat model of fragile X syndrome.

Single-nucleus RNA sequencing identifies brain cell types with significant changes in gene expression in autism Using single-nucleus RNA sequencing of postmortem cortical tissue from individuals with ASD, Arnold Kriegstein and colleagues identify upper-layer excitatory neurons and microglia as key cell types affected in ASD.

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