Ethan Greenblatt is a postdoctoral fellow at Carnegie Institution for Science. He received his doctoral training in the laboratory of Ron Kopito at Stanford University, where he worked on cellular protein quality control mechanisms, showing a central role for membrane ‘pseudo’-proteases in the proteasomal degradation of misfolded secretory proteins.
Greenblatt went on to join the laboratory of Allan Spradling at Carnegie Institution for Science’s Department of Embryology in Baltimore, Maryland, for postdoctoral training. Greenblatt utilized the developmental biology of the Drosophila ovary to uncover mechanisms of post-transcriptional gene regulation underlying prolonged oocyte function, including a role for the fragile X mental retardation 1 (Fmr1) gene in activating the translation of large proteins critical for homeostasis. He now plans to use genetic, genomic and proteomic strategies to gain insights into the molecular mechanism underlying Fmr1-mediated translational activation and to uncover new therapeutic targets for the development of treatments for fragile X-associated neuronal and reproductive disorders.