Tag: TSC2

September 29, 2020

SFARI spring 2020 science meeting goes online By Michele Solis

July 23, 2019

A Conversation with SFARI Investigator Dan Feldman By Michele Solis

February 25, 2019

Alterations in neuronal excitability are compensatory changes, not causal effects, in autism

November 26, 2018

SFARI 2018 Explorer awardees announced

November 26, 2018

SFARI workshop revisited the excitation-inhibition hypothesis of autism By Serena Bianchi

May 01, 2018

SFARI Gene: New data release

Normal human chromosomes visualized by spectral karyotyping (SKY). Spectral karyotyping is a molecular cytogenetic technique used to simultaneously visualize all the pairs of chromosomes in an organism in different colors. Fluorescently labeled probes for each chromosome are made by labeling chromosome-specific DNA with different fluorophores. Because there are a limited number of spectrally distinct fluorophores, a combinatorial labeling method is used to generate many different colors. Spectral differences generated by combinatorial labeling are captured and analyzed by using an interferometer attached to a fluorescence microscope. Image processing software then assigns a pseudo color to each spectrally different combination, allowing the visualization of the individually colored chromosomes. This technique is used to identify structural chromosome aberrations in cancer cells and other disease conditions when Giemsa banding or other techniques are not accurate enough.

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