Tomasz Nowakowski, Ph.D.

Assistant Professor, University of California, San Francisco

SFARI Investigator Website

The central goal of Tomasz Nowakowski’s research is to understand how the human genome reproducibly generates the diverse phenotypes of pyramidal cells according to an inherited developmental program and how genomic abnormalities impact these developmental processes and underlie the etiology of neurodevelopmental disorders. Nowakowski is especially interested in combining medical genetics and genome biology predictions of disease risk variants with functional annotations of cell identity to uncover cellular convergence of disease risk factors in autism spectrum disorder and other neurodevelopmental disorders.

Funded Projects

Cell-type specificity of autism risk factors in the developing human brain

Awarded: 2018
Award Type: Bridge to Independence

SFARI Funded Publications

Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids. Popova G., Soliman S.S., Kim C.N., Keefe M.G., Hennick K.M., Jai S., Li T., Tejera D., Shin D., Chhun B.B., McGinnis C.S., Speir M., Gartner Z.J., Mehta S.B., Haeussler M., Hengen K.B., Ransohoff R.R., Piao X., Nowakowski T.

Single-cell epigenomics reveals mechanisms of human cortical development. Ziffra R.S., Kim C.N., Ross J.M., Wilfert A., Turner T.N., Haeussler M., Casella A.M., Przytycki P.F., Keough K.C., Shin D., Bogdanoff D., Kreimer A., Pollard K.S., Ament S.A., Eichler E., Ahituv N., Nowakowski T.

Integrated gene analyses of de novo mutations from 46,612 trios with autism and developmental disorders. Wang T., Kim C., Bakken T.E., Gillentine M.A., Henning B., Mao Y., Gilissen C., SPARK Consortium, Nowakowski T., Eichler E.