

Funded Projects
Understanding the cellular and circuit bases for behavioral impairments in the Scn2a knock-out rat
Awarded: 2022
Award Type: Targeted: Autism Rat Models Consortium
Award Type: Targeted: Autism Rat Models Consortium
CRISPR activation-based approach to rescue cellular and behavioral deficits associated with Scn2a haploinsufficiency
Awarded: 2019
Award Type: Director
Award Type: Director
Cellular and circuit effects of SCN2A haploinsufficiency
Awarded: 2017
Award Type: Pilot
Award Type: Pilot
SFARI Funded Publications
Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites.
Nelson A.D., Catalfio A.M., Gupta J.M., Min L., Caballero-Florán R.N., Dean K.P., Elvira C.C., Derderian K.D., Kyoung H., Sahagun A., Sanders S., Bender K., Jenkins P.
CRISPR activation rescues abnormalities in SCN2A haploinsufficiency-associated autism spectrum disorder.
Tamura S., Nelson A.D., Spratt P.W.E., Kyoung H., Zhou X., Li Z., Zhao J., Holden S.S., Sahagun A., Keeshen C.M., Lu C., Hamada E.C., Ben-Shalom R., Pan J.Q., Paz J.T., Sanders S., Matharu N., Ahituv N., Bender K.
LiCl treatment leads to long-term restoration of spine maturation and synaptogenesis in adult Tbr1 mutants.
Darbandi S.F., Nelson A.D., Pai E.L., Bender K., Rubenstein J.