Alfred George is the Magerstadt Professor and chair of the Department of Pharmacology and director of the Center for Pharmacogenomics at Northwestern University Feinberg School of Medicine. George received his medical education at the University of Rochester in 1982, followed by residency training at Vanderbilt University and a clinical fellowship at University of Pennsylvania. He developed expertise in the molecular genetics of ion channels initially as a research fellow at the Institut Suisse de Recherches Experimentales sur le Cancer in Lausanne, Switzerland, then later, as a fellow in the Departments of Medicine and Biochemistry and Biophysics and the Institute for Neurological Sciences at University of Pennsylvania.
George has been a pioneer in elucidating the genetics and pathogenesis of channelopathies — disorders caused by mutations in ion channel genes. His work focuses on genetic disorders caused by voltage-gated ion channel mutations that are responsible for disorders of membrane excitability, including diseases affecting muscle, heart and brain. George has been involved from the beginning of the channelopathy field, making enduring contributions to revealing the molecular genetic basis for several disorders, elucidating the functional consequences of dozens of mutant ion channels and helping to translate discoveries into new therapeutic strategies for these orphan diseases.