Genomic Analysis for Autism Risk Variants in SPARK – Request for Applications

Grants awarded through this RFA are intended to advance our understanding of the genetic basis of autism. Investigators who are interested in analyzing genomic data in innovative ways from thousands of SPARK families are encouraged to apply.

Available data will include whole-exome and genome-wide genotyping data from approximately 4,500 individuals with autism spectrum disorder (ASD) and their biological parents. Approximately half of these families will also have genomic data from an unaffected sibling. In addition, whole-genome sequencing data will be available from approximately 400 other ASD individuals, plus their biological parents and unaffected siblings. A limited phenotypic dataset for all participants will be available.

We expect to fund several awards in the range of $100,000 (direct costs) for 18 months. Higher budgets will be considered, but we expect such budgets to be strongly justified.

Maximum Budget

Budget: $100,000 (direct costs)
Funding Duration: 18 months

Important Dates
  • Application Available
  • Notice of Intent Deadline
  • Full Proposal Deadline
  • Award Notification
  • Award Start Date
Contact Info

Background

SPARK (Simons Foundation Powering Autism Research for Knowledge) is an autism research initiative that aims to recruit, engage and retain a community of 50,000 individuals with autism and their family members living in the U.S. Participation in this cohort will involve contribution of medical and behavioral information, mailing in of saliva for genetic analysis, the option to have genetic findings related to autism returned, and consent to be invited to participate in future research studies.

The project is operated by the Simons Foundation Autism Research Initiative (SFARI) in collaboration with approximately 25 university-affiliated research clinics, whose roles are to help enroll individuals with autism and their families in the study. Numerous national and local autism community organizations across the U.S. are also helping to find research participants and spread the word about this landmark initiative.

To date, SPARK has collected DNA extracted from saliva samples from thousands of individuals affected with autism and their family members. Phenotypic data for these families were collected online and are available through SFARI Base and summarized here: https://www.sfari.org/resource/spark/. SFARI has released whole-exome and genome-wide genotyping data from approximately 500 individuals with ASD and their biological parents. In October 2018, SFARI expects to release whole-exome and genome-wide genotyping data from  approximately 4,500 additional individuals with ASD, their biological parents and an unaffected sibling (when available). SFARI also expects to release whole-genome data from an additional 400 individuals with ASD, their biological parents and an unaffected sibling (when available). The genomic data on SPARK participants expected to be available in October 2018 is summarized in the table below.

Laboratory
(# of samples)
# of Families Exome or Genome Sequencing? Exome capture reagent
(if applicable)
Genotyping chip
Baylor Human Genome Sequencing Center 
(n = 1,401 samples)
464 ASD families (affected individual/s + biological parents) Exome 
(mean coverage: 80X)
VCRome + PKv2 Illumina Human Exome cSNP
Regeneron 
(n = 13,324 samples)
4,011 ASD families (affected individual/s + biological parents + unaffected sibling when available) Exome
(minimum of 20X at 85% of targeted bases)
IDT xGEN Exome Research Panel v1.0 Illumina Global Screening Array
New York Genome Center 
(n = 1,476)
369 ASD families (affected individual/s + biological parents + unaffected sibling when available) Genome
(estimated average coverage: 30X)
Illumina Human Core Exome

Objective of this Award

This RFA seeks proposals that will advance our understanding of the genetic basis of autism. SFARI welcomes proposals that focus on any type of genetic variants (rare and common variants, single-nucleotide variants (SNVs), copy number variants (CNVs), indels, coding and noncoding variants) that contribute to autism risk. We encourage innovative applications that combine analyses of variants across the allele frequency spectrum. We will prioritize proposals that will analyze SPARK data in conjunction with available genomic data from other ASD and neurodevelopmental genetic cohorts.

SFARI will make the alignment and variant call data available to all eligible researchers (i.e., not only those funded through this RFA) following standard quality control and data processing steps. The first batch of data is already available on SFARI Base, and the remaining data will be made available around October 2018. There will be a publication embargo for six months after all genomic data are released, which will prohibit submission of manuscripts for publication.

SFARI will work with successful applicants to make the genomic data available to their academic or cloud-based computing resources. SFARI understands that validation of de novo variants in recurrent genes/pathways is a key aspect of this project and will coordinate experimental confirmation of de novo calls with awardees.

Eligibility and collaboration

All applicants and key collaborators must hold a Ph.D., M.D. or equivalent degree and have a faculty position or the equivalent at a college, university, medical school or other research facility. Applications may be submitted by domestic and foreign nonprofit organizations; public and private institutions, such as colleges, universities, hospitals, laboratories, and units of state and local government; and eligible agencies of the federal government. Applications may also be submitted by for-profit companies, in which case the funds provided for the grant are to be used only for charitable purposes to fund research related to ASD. There are no citizenship or national residence requirements.

If the proposal includes investigators at more than one site, all investigators should have demonstrated prior success in similar collaborations.

Funding period and budget

The grant period is 18 months. We expect to fund several awards in the $100,000 range (direct costs). Exceptions with good justification will be considered but are not encouraged.

Application requirements

Applications should include the following:

  1. Narrative, not to exceed six pages (excluding references, figures and figure legends). Proposals should include specific aims, background relevant to the application, significance of the proposed studies, preliminary results, experimental design, pitfalls and alternative strategies, and a timeline with milestones.
  2. Biosketches for Principal Investigator(s) and key collaborators.
  3. Current and pending support for Principal Investigator(s) and key collaborators.
  4. Budget. We expect to fund several awards in the $100,000 range (direct costs). Exceptions with good justification will be considered but are not encouraged. Proposals should include a realistic budget sufficiently detailed for evaluation of needed resources. SFARI will work closely with investigative teams with competitive applications to arrive at a suitable budget. Indirect costs are limited to 20 percent of the modified total direct costs (see Simons Foundation policies).
  5. Applicants should detail a strategy and estimate a budget for orthogonal confirmation of applicant’s specific variants of interest. But note that SFARI will coordinate and directly fund the validation of variants in a centralized fashion.
  6. Applicants should detail a strategy and estimated budget for computing costs (either cloud or academic computing facility). SFARI will pay directly for cloud storage costs, so these costs need not be included in the applicant’s budget.
  7. Applications with multiple Principal Investigators from different institutions who would like to be paid separately must include a signed budget template and budget justification for each Principal Investigator’s institution. Applications with subcontracts must include a budget and budget justification. The budget template and budget justification are available for download in the proposal attachments section of proposalCENTRAL’s full application.
  8. Research environment and resources. Investigators should demonstrate access to appropriate resources for high-capacity data analysis and computation.
  9. Data-sharing plan. The plan should include the sharing of all analyzed data in addition to the sharing of any new algorithms/data visualization tools that are a direct result of this award. SFARI will work closely with awarded investigative teams to ensure that the plan includes timely dissemination of data.

For more details, see the Instructions document, which is available for download in the proposal attachments section of proposalCENTRAL.

Application Deadline

We request that investigators who intend to submit a proposal send an email by June 22, 2018, with the intended investigators’ names and affiliations and their intended proposal’s title to grants@simonsfoundation.org with the subject line: SPARK Genomic RFA Notice of Intent.

The deadline for full proposal submission is July 27, 2018. No extensions will be given. If you have any difficulties, please contact grants@simonsfoundation.org.

Competitive applications will receive external peer review. SFARI will make final funding decisions; notification of award is anticipated by November 14, 2018, with funding expected to begin December 1, 2018.

Instructions for Submission

Applications must be completed electronically and submitted using forms provided at proposalCENTRAL. Please log in as an applicant, scroll to “Simons Foundation” and click on the program.

Contacts

Scientific inquiries:
sciencerfa@simonsfoundation.org
646-654-0066

Administrative inquiries:
grants@simonsfoundation.org
646-654-0066

SPARK data and recruitment questions:
collections@sfari.org
646-654-0066

proposalCENTRAL:
pcsupport@altum.com
800-875-2562

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proposalCENTRAL Logo

The Simons Foundation uses an electronic grants submission process. All interested grant applicants must submit their applications online through proposalCENTRAL.

Maximum Budget

Budget: $100,000 (direct costs)
Funding Duration: 18 months

Important Dates
  • Application Available
  • Notice of Intent Deadline
  • Full Proposal Deadline
  • Award Notification
  • Award Start Date
Contact Info

The deadline for application submission is Friday, July 27, 2018, at 5 p.m. EDT.

proposalCENTRAL Login Information
Prospective applicants must submit an application via proposalCENTRAL (pC). To start an application in pC, users must first login to their pC account.

If You Need to Create a New Account in pC
To create a new account, go to proposalCENTRAL and click CREATE ONE NOW under APPLICATION LOGIN. Fill in the required fields, check the boxes to agree to pC’s “Terms of Service” and “Acceptable Use Policy” and then click SAVE.
If You Have an Existing Account in pC
For all users with a pC account, log in under APPLICATION LOGIN at proposalCENTRAL and select CREATE NEW PROPOSAL or click on the GRANT OPPORTUNITIES tab. Scroll down to SIMONS FOUNDATION and then click APPLY NOW for the “Simons Foundation Autism Research Initiative – Genomic Analysis for Autism Risk Variants in SPARK” program in order to start the proposal and access the templates. After all sections are completed, you will be able to click on the SUBMIT button to send.

To submit a full application, the following proposalCENTRAL sections must be completed:

  1. Title Page: Enter proposal title in this section.
  2. Download Templates and Instructions: All templates necessary to complete your proposal are available for download in this module (or the PROPOSAL ATTACHMENTS module, where attachments are submitted as PDF-only files; see the “Proposal Attachments” section below for more details).
  3. Enable Other Users to Access this Proposal: This section allows you to give other users access to your grant application. You have the option of giving them one of three levels of permission: View, Edit or Administrator.
  4. Applicant/PI: The Principal Investigator (PI) should be listed here. For grants with multiple PIs, the contact PI should be listed here.
  5. Organization/Institution: Contact information for the signing official and financial/fiscal officer from your institution is required; select the correct person or enter new names in this section.
  6. Key Personnel: Indicate Key Personnel, including but not limited to: PIs, Co-investigators, Consultants and Postdoctoral Research Associates. In rare circumstances, the applicant organization may designate multiple individuals as PIs who share the authority and responsibility for leading the project, intellectually and logistically. For more information on the responsibilities of PIs, please refer to the personnel definitions in the Genomic Analysis RFA FAQ.
  7. Abstracts: Enter the Abstracts as text in this section.
  8. Budget Period Detail: Enter your budget period detail in this section.
    1. Award start date: Proposals selected for funding will be announced by November 14, 2018, and funding will begin on December 1, 2018.
    2. Indirect costs (IDC): IDCs are limited to 20 percent of direct costs, with the following exceptions: equipment, tuition, and any subcontracts with budgets including IDCs. IDCs paid to a subcontractor may not exceed 20 percent of the direct costs paid to the subcontractor. While IDCs on equipment are not allowable, IDCs on small equipment (equipment up to $10,000) are permissible.
    3. Equipment: The Simons Foundation (SF) will own equipment purchased with SF grant funds with a unit cost of $50,000 or more. At the end of the grant funding period or in the case of grant termination for any reason, SF reserves the right to retain ownership or cede ownership to the PI’s institution. Equipment with a unit cost of less than $50,000 shall be the property of the institution.
    4. Budget: Awards will be made in the range of $100,000 (not including indirect costs), for a period of 18 months. Exceptions with good justification will be considered but are not encouraged. Proposals should include a realistic budget sufficiently detailed for evaluation of needed resources. SFARI will work closely with investigative teams with competitive applications to arrive at a suitable budget. Applicants should detail a strategy and estimate a budget for computing costs (either cloud or academic computing facility). SFARI will pay directly for cloud storage costs, so these costs need not be included.
    5. Multiple PIs:
      1. Please note that the applicant PI will be the designated Contact PI for the project. The Contact PI will be responsible for directing the project and will act as the main point of contact for the foundation by coordinating all administrative deliverables.
      2.  

      3. Applications with multiple PIs from different institutions who would like to be paid separately must upload in the PROPOSAL ATTACHMENTS section:
        1. Signed signature page for each PI (available for download in the PROPOSAL ATTACHMENTS and DOWNLOAD TEMPLATES AND INSTRUCTIONS sections).
        2.  

        3. Budget Template for each non-applicant PI (available for download in the PROPOSAL ATTACHMENTS and DOWNLOAD TEMPLATES AND INSTRUCTIONS sections).
        4.  

        5. The direct and indirect costs for all non-applicant PIs. Direct costs must be included in Section 8 (Budget Period Detail) in the CONSORTIUM & CONTRACTUAL DIRECT section, and indirect costs should be included in the INDIRECT COSTS section. Please enter both direct costs and indirect costs for each non-applicant PI on separate lines.

         

      4. Applications with multiple PIs from different institutions who will be paid directly by the contact PI’s institution are considered subcontracts. Please refer to the subcontract instructions in the section below.
      5.  

      6. Applications with multiple PIs from the same institution do not need to submit additional materials. Additional non-applicant PIs should be listed as Key Personnel in section 6 (KEY PERSONNEL) and Section 8 (BUDGET PERIOD DETAIL), and only one signature page is needed.
    6. Subcontracts:
      1. Applications with subcontracts (including PIs who will be paid directly by the contact PI’s institution) must submit:
        1. Subcontract Detailed Budget (available for download in the PROPOSAL ATTACHMENTS and DOWNLOAD TEMPLATES AND INSTRUCTIONS sections) for each subcontract.
        2.  

        3. Subcontract direct and indirect costs. Subcontract direct costs must be included in the CONSORTIUM & CONTRACTUAL DIRECT section, and subcontract indirect costs should be included in the INDIRECT COSTS section. Please enter both direct costs and indirect costs for each subcontract on separate lines.
  9. Budget Summary: The Budget Summary will be populated from the saved detailed budget.
  10. Organization Assurances: Indicate use of human participants or vertebrate animals in this section and status of approval from the institutional review board or Institutional Animal Care and Use Committee. Grants cannot activate without current human participant and/or animal research ethical approval.
  11. Proposal Attachments: The following documents are to be uploaded in this section, where they are also available for download:
    1. Proposal narrative: The proposal narrative should not exceed six (6) pages of single-spaced, size 11 text, with 0.5-inch margins. The narrative should describe the specific aims of the project, background relevant to the application, significance of the proposed studies, preliminary results, experimental design, pitfalls and alternative strategies, relevance to autism, timeline, and milestones. Figures and figure legends are not included in the page limit and should be included in the narrative PDF document. SF’s preference is for figures to follow the narrative rather than be embedded in the text. References are also not included in the page limit; please include them at the end of the narrative in the same PDF file.
    2. Biographical sketch of Key Personnel
    3. Budget justification
    4. Budget templates:
      1. Multiple PIs: Applications with multiple PIs from different institutions who would like to be paid separately must submit a signed budget template for each PI institution.
      2.  

      3. Subcontract: Applications with subcontracts must submit a budget template.
    5. Research environment and resources: PIs should demonstrate access to appropriate resources for high-capacity data analysis and computation.
    6. Renewable reagents and data-sharing plan: The plan should include the sharing of all analyzed data in addition to the sharing of any new algorithms/data visualization tools that are a direct result of this award. SFARI will work closely with awarded investigative teams to ensure that the plan includes timely dissemination of data.
    7. Current and pending support: Please upload current and pending support for both PI(s) and Key Personnel.
    8. Signed signature page: Applications with multiple PIs from different institutions who would like to be paid separately must submit a signed signature page from each PI institution.
  12. PI data sheet: Your professional profile will populate this section of the application. If revisions are required, please select EDIT PROFESSIONAL PROFILE and go to section 4 (PERSONAL DATA FOR APPLICATIONS).
  13. Validate: You must click the VALIDATE button to check for any missing required information or files. All missing required information will be listed on the screen. Please supply any missing information before proceeding to the next step.
  14. Signature page(s): The signed signature page is available for download in this section and must be signed by the signing official, then re-uploaded in the PROPOSAL ATTACHMENTS section. Applications with multiple PIs from different institutions who would like to be paid separately must submit a signed signature page for each PI institution.
  15. Submit: You will be unable to submit if you have not provided all the required information. Any missing information will be listed on the screen. If your submission is successful, you will receive a confirmation message on the screen and a confirmation email.

Please note that narratives exceeding six (6) pages (not including figures, figure legends and references) will not be reviewed. No extensions will be given.

Contacts

Administrative inquiries:
grants@simonsfoundation.org
646-654-0066

Scientific inquiries and requests:
sciencerfa@simonsfoundation.org
646-654-0066

SPARK data and recruitment questions:
collections@sfari.org
646-654-0066

proposalCENTRAL:
pcsupport@altum.com
800-875-2562

Read More
Maximum Budget

Budget: $100,000 (direct costs)
Funding Duration: 18 months

Important Dates
  • Application Available
  • Notice of Intent Deadline
  • Full Proposal Deadline
  • Award Notification
  • Award Start Date
Contact Info
  • proposalCENTRAL Login Instructionsplus--large
      Where do I submit my application proposal?plus--large

      Applications are online and must be submitted online through proposalCENTRAL. New users first need to create a user account on proposalCENTRAL (https://proposalcentral.altum.com/). For instructions on how to create a user account, please see question 2 below. For all users, log in and select “Create New Proposal” or click on the “Grant Opportunities” tab. Filter the Grant Maker by “Simons Foundation” and click on “Apply Now” next to the “Genomic Analysis for Autism Risk Variants in SPARK Request for Applications” program. Once all sections are complete and the attachments are uploaded, the “Submit” button will be activated.

      How do I create a proposalCENTRAL user account?plus--large

      Go to https://proposalcentral.altum.com/ and click “Create one now” under “Need an account?” Fill in the required fields, check the boxes to agree to proposalCENTRAL’s terms of service and acceptable use policy, and then click “Save.”

  • Eligibilityplus--large
      Can postdoctoral associates apply as Principal Investigators?plus--large

      No, postdoctoral associates may not apply as PIs. All applicants and key collaborators must hold a Ph.D., M.D. or equivalent degree and have a faculty position or the equivalent at a college, university, medical school or other research facility.

      Can multiple Principal Investigators apply for a grant?plus--large

      Yes. If the proposal includes multiple PIs at more than one site, all investigators should have demonstrated prior success in similar collaborations.

      For projects that have multiple PIs at different institutions, applications must be submitted by the PI designated as the contact PI and his/her institution. All applicants and key collaborators must hold a Ph.D., M.D. or equivalent degree and have a faculty position or the equivalent at a college, university, medical school or other research facility, and must submit a biosketch and a list of current and pending support.

      Applications with multiple PIs from different institutions who will be paid directly by the contact PI’s institution are considered subcontracts.

      Can foreign institutions apply for a grant?plus--large

      Yes. Please upload, if available, a copy of your U.S. Internal Revenue Service (IRS) 501(c)(3) determination or equivalency letter as part of the application. The Simons Foundation requires a determination letter from the IRS stating exemption under 501(c)(3) and, furthermore, a 509(a)(1), (2) or (3) classification. If an international institution is selected for funding and does not have this documentation, the Simons Foundation will require the institution to complete an equivalency determination with NGOsource (see Simons Foundation policies).

      Can for-profit companies apply for a grant?plus--large

      Applications may be submitted by for-profit companies, in which case the funds provided for the grant are to be used only for charitable purposes to support research related to autism spectrum disorders.

      How are applicants selected?plus--large

      Applicants will be selected based on qualifications and experience with the topic(s) relevant to the program. Competitive applications will receive external peer review. Notification of application status is expected by November 14, 2018.

  • Submission Instructionsplus--large
      Is the Notice of Intent required to submit a full application? Is it the same as a Letter of Intent (LOI)?plus--large

      No, the Notice of Intent is not required for application submission, but we request that investigators who intend to submit a proposal send an email by June 22, 2018, with the intended investigators’ names and affiliations and their intended proposal’s title to grants@simonsfoundation.orgwith the subject line: SPARK Genomic RFA Notice of Intent.

      The Notice of Intent is not the same as a formal Letter of Intent. Approval is not required for application submission.

      Can someone else (assistant, staff member, etc.) submit my application for me?plus--large

      Yes, you can add users with administrator access to the proposalCENTRAL application so that someone other than the Principal Investigator (PI) can edit and submit the application. To add another user, go to section 3, “Enable Other Users to Access This Proposal,” and complete the required fields.

      Is validating my proposal the same as submitting it?plus--large

      No. Validating checks for errors and omissions and will alert you to missing application requirements. If the application is complete, you must then click “Submit.” You will receive an email within 10 minutes, and you should contact pcsupport@altum.com if you do not receive confirmation and do not see your application in the “Submitted” drop-down tab or with the status changed to “Submitted.”

      I get an error message citing a missing section when I try to submit.plus--large

      The “Validate” button reviews your application for missing sections. The submission instructions list the required sections and attachments. You must complete the missing sections listed. If you are still receiving error messages after completing and saving the indicated sections, please contact pcsupport@altum.com.

      Where is the “Submit” button?plus--large

      The “Submit” button is located in the last section of the application. You will be unable to submit if you have not provided all the required information. If your application is complete and you are unable to submit it, please contact pcsupport@altum.com.

      Can I make changes to the application once it has been submitted?plus--large

      You must contact the Simons Foundation to un-submit your full application before you can edit attachments or HTML sections. Please email grants@simonsfoundation.org or call 646-654-0066 if you would like to un-submit your application prior to the July 27, 2018, deadline.

      Will I receive a confirmation email when I submit?plus--large

      A confirmation email is sent upon submission of the application. Please contact pcsupport@altum.com if you submitted your application and have not received a confirmation email within 10 minutes. Make sure that your spam filters allow emails from pcsupport@altum.com.

  • Full Proposal Requirementsplus--large
      Does the Simons Foundation require letters of support or collaboration?plus--large

      We do not require letters of support or letters of collaboration for Co-investigators.

      Is there a minimum percent effort for Principal Investigators or Co-investigators?plus--large

      There is no minimum percent effort requirement for any personnel, but we expect personnel, in particular PIs and Co-investigators, to have efforts that reflect their roles in the project.

      What is required for a subcontract? Where do I add the subcontract budget and upload subcontract budget details?plus--large

      Applications with subcontracts must submit a subcontract budget for each subcontract awardee and grant year. The applicant PI must include the direct-cost budget totals for all subcontracts in the “Consortium & Contractual Direct” section and indirect costs for all subcontracts in the “Subcontract Indirect Costs”section. The subcontract budget can be downloaded and uploaded in the “Proposal Attachments” section of the full application on proposalCENTRAL.

      What is the funding period? When will funding begin?plus--large

      The funding period is for 18 months in the range of $100,000, not including 20 percent of the modified total direct costs (see Simons Foundation policies), beginning December 1, 2018.

      Are references, figures and figure legends included in the narrative six-page limit? How should they be included?plus--large

      References, figures and figure legends are not included in the page limit for the full proposal. Please attach them at the end of the six-page narrative in the same PDF file. The Simons Foundation’s preference is for figures to follow the narrative rather than be embedded in the text.

      What can I include as an appendix?plus--large

      ‘In-press’ papers can be included as appendices, as well as any papers that you consider essential for the work of the review committee (not more than three). Any other material should be included, if possible, in the narrative.

      If you have video attachments for your proposal, please upload them as an appendix (all file types are accepted). All appendices should be uploaded in the “Proposal Attachments” section of the application.

      What are the font, font size and margin requirements?plus--large

      11-point, legible font and 0.5-inch margins.

      Does the Principal Investigator need to sign the signature page?plus--large

      No, only the signing official is required to sign the signature page.

      Do researchers need to send a copy of manuscripts to SFARI in parallel to submitting to a journal?plus--large

      Yes, researchers must send a copy of manuscripts to SFARI in parallel to submitting to journals.

  • Access to data and biospecimens from the SPARK Cohortplus--large
      How can I find out more about available phenotypic data available from SPARK?plus--large

      You can access and request information about SPARK data on SFARI Base. Please see our SPARK resources website for more information (https://www.sfari.org/resource/spark/). If you do not have a SFARI ID, you must create one. If you have problems with the login or have questions regarding the collections, please email collections@sfari.org.

  • SFARI Glossaryplus--large
      Personnel definitionsplus--large

      Principal Investigator

      The individual(s) judged by the applicant organization to have the appropriate level of authority and responsibility to direct the project or program supported by the grant. All Principal Investigators (PIs) must hold a Ph.D., M.D. or equivalent degree and have a faculty position or the equivalent at a college, university, medical school or other research facility. He or she is responsible and accountable to the applicant organization and SFARI for the proper conduct of the project or activity, including the submission of all required reports. He or she will act as the main point of contact for the foundation. There is no minimum percent effort required for a PI, but it is expected that the PI will join the collaborative community of SFARI Investigators and that he or she will take part in some of the conferences, workshops and symposia that the foundation organizes.

      The applicant organization may designate multiple individuals as PIs who share the authority and responsibility for leading and directing the project, intellectually and logistically. Each PI is responsible and accountable to the applicant organization or, as appropriate, to a collaborating organization for the proper conduct of the project or program, including the submission of all required reports. The presence of more than one identified PI on an application or award diminishes neither the responsibility nor the accountability of any individual PI.

      The PI under whose name the application is submitted will serve as the contact PI for administrative purposes. The contact PI must be affiliated with the institution submitting the application. The contact PI will be responsible for communication between SFARI and the rest of the leadership team.

      The role type ‘Co-PI’ will not be used by SFARI. 

      Co-investigator

      An individual involved with the PI in the scientific development or execution of a project. The Co-investigator must hold a Ph.D., M.D. or equivalent degree and be employed by, or be affiliated with, the applicant/grantee organization or another organization participating in the project under a consortium agreement. A Co-investigator is considered Key Personnel, but the Simons Foundation does not require a minimum effort from the Co-investigator. The designation of a Co-investigator, if applicable, does not affect the PI’s roles and responsibilities, nor is it a role implying multiple PIs.

      Consultant

      An individual providing professional advice or services on the basis of a written agreement. Consultants are not normally employees of the organization receiving the services. Consultants also include firms providing professional advice or services.

      Postdoctoral Research Associate or equivalent employee position

      An individual who has received a doctoral degree (or its equivalent) and is engaged over a temporary and defined period in mentored advanced training to enhance the professional skills and research independence needed to pursue his or her chosen career path. The Postdoctoral Research Associate performs specific services in exchange for compensation, and he or she is treated as an employee of the grantee institution, with benefits.

      SFARI funds may be used only for personnel who are employees of the grantee institution and eligible for benefits. Funds may not be used for stipend supplementation unless specifically authorized under the terms of the program from which funds are derived.

SPARK

  • Awarded: 2016
  • Award Type: SPARK

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