This RFA seeks proposals that aim to comprehensively analyze the behavior of mouse models that have been generated with targeted genetic mutations based on strong human genetic evidence implicating them in autism spectrum disorders. We expect investigators will test at least three genetic models in the same background strain (C57BL/6). In addition, investigators should analyze the behavior of one of the selected autism mouse models in a different genetic background, such as a hybrid background from two inbred strains. Proposals should include: 1) sophisticated automation in data collection, 2) long-term monitoring of spontaneous behavior, 3) an analysis of both sexes, and 4) a minimum of three developmental time-points, particularly those during critical periods of brain development.