Innate Immune System Impact Request for Applications

Grants awarded through this RFA were intended to advance our understanding of the impact of activation of the innate immune system on behavioral, circuit, synaptic and neuronal functions in order to understand the consequences of infection and immune activation on autism-related behaviors. Experiments were expected to include physiologically relevant activation/inhibition of the innate immune system in animal models of autism and to focus on neuronal, synaptic and circuit function.

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Important Dates
  • Application Deadline
  • Notification of Award
  • Funding Expected to Begin
Important Dates
  • Application Deadline
  • Notification of Award
  • Funding Expected to Begin
Contact Info
Important Dates
  • Application Deadline
  • Notification of Award
  • Funding Expected to Begin
Contact Info

Grants awarded through this request for applications (RFA) were intended to advance our understanding of the impact of activation of the innate immune system on behavioral, circuit, synaptic and neuronal functions in order to understand the consequences of infection and immune activation on autism-related behaviors.

To this end, we sought applications for investigations of the impact of physiologically relevant activation of the innate immune system on behavioral, circuit, synaptic and neuronal functions in animal models of autism. SFARI especially encouraged applications that address either of the following two issues:

(1) Effects of activation of the maternal innate immune system on embryonic central nervous system development in genetic models of autism and controls. How do fetal genetics and maternal innate immune activation interact to affect postnatal autism-related phenotypes, and what are the mechanisms through which they interact?

(2) Effects of activation of the innate immune system in genetic autism models and adult controls. How does innate immune activation affect behavioral, circuit, synaptic and cellular function in these genetic models and in controls? What are the roles of cytokine signaling, fever, immune cell activation and other effectors on these functions?

Important Dates
  • Application Deadline
  • Notification of Award
  • Funding Expected to Begin
Contact Info

Instructions for submission

Applications must be completed electronically and submitted using forms provided at proposalCENTRAL. Please log in as an applicant, scroll to ‘Simons Foundation’ and click on the program.

 

Contacts

 

Scientific inquiries:   [email protected]    646-654-0066
Administrative  inquiries:   [email protected]    646-654-0066
proposalCENTRAL:   [email protected]    800-875-2562
Important Dates
  • Application Deadline
  • Notification of Award
  • Funding Expected to Begin
Contact Info
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