Analysis of Simons VIP Biospecimens Request for Applications
This RFA sought proposals that take advantage of the unique combination of biospecimens and rich phenotypic information collected by Simons VIP. Although SFARI was open to many different approaches, we gave priority to those that aim to accomplish a comprehensive characterization of RNA expression differences and correlate such expression patterns with phenotypes. Furthering the ability to include genomic analysis was considered be an additional strength. The data produced in this effort was later made available to the research community.
- Application Deadline
- Notification of Award
- Funding Expected to Begin
- Application Deadline
- Notification of Award
- Funding Expected to Begin
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SFARI Grant Programs
[email protected]
- Application Deadline
- Notification of Award
- Funding Expected to Begin
-
SFARI Grant Programs
[email protected]
The Simons Variation in Individuals Project (now known as Simons Searchlight) comprises a large cohort of individuals with a deletion or duplication of chromosomal segment 16p11.2 (approximately 100 deletion and 100 duplication carriers). A wealth of phenotypic (behavioral, neurological and neuroimaging) data has been collected from these individuals and their families. The data collected so far emphasize significant phenotypic variability: About 20 percent of deletion and duplication carriers meet strict criteria for an autism diagnosis; many other carriers have other neuropsychiatric diagnoses, including a high rate of language difficulties.
This request for applications sought proposals that take advantage of the unique combination of biospecimens and rich phenotypic information collected by Simons VIP. Although SFARI was open to many different approaches, we gave priority to those that aim to accomplish a comprehensive characterization of RNA expression differences and correlate such expression patterns with phenotypes. Furthering the ability to include genomic analysis was considered be an additional strength. The data produced in this effort was later made available to the research community.
- Application Deadline
- Notification of Award
- Funding Expected to Begin
-
SFARI Grant Programs
[email protected]
Instructions for submission
Applications must be completed electronically and submitted using forms provided at proposalCENTRAL. Please log in as an applicant, scroll to “Simons Foundation” and click on the program.
Contacts
Scientific inquiries: [email protected] 646-654-0066
Administrative inquiries: [email protected] 646-654-0066
proposalCENTRAL: [email protected] 800-875-2562
- Application Deadline
- Notification of Award
- Funding Expected to Begin
-
SFARI Grant Programs
[email protected]
-
Frequently Asked Questions
How do I submit a full proposal?
New users first need to register on proposalCENTRAL. For all users, log in and select “Create New Proposal” or click on the “Grant Opportunities” tab. Filter the Grant Maker by “Simons Foundation” and click on “Apply Now” next to the “Analysis of Simons VIP Biospecimens” program. Once all sections are complete and the attachments are uploaded, the “Submit” button will be activated.
Are references, figures and figure legends included in the narrative six (6)-page limit? How should they be included?References, figures and figure legends are not included in the page limit for the full proposal. Please attach them at the end of the six (6)-page narrative in the same PDF file. The Simons Foundation’s preference is for figures to follow the narrative rather than be embedded in the text.
What are the font and size requirements?11-point, legible font.
What can I include as an appendix?‘In-press’ papers can be included as appendices, as well as any papers that you consider essential for the work of the review committee (not more than three [3]). Any other material should be included, if possible, in the narrative. If you have video attachments for your proposal, please upload as an appendix (all file types are accepted).
How can I find out more about available biospecimens and other data available from the Simons Variation in Individuals Project (Simons VIP)?You can access and request information about Simons VIP biospecimens and data on SFARI Base. If you do not have a SFARI ID, you must create one. If you have problems with the log-in or have questions about the availability of biospecimens or data, please email [email protected].
Does the Simons Foundation require letters of support or collaboration?We do not require letters of support or letters of collaboration for Co-investigators. If a letter is prepared, it can be uploaded as “Appendix: In-press papers on related topics.”
s there a minimum percent effort for Principal Investigators or Co-investigators?There is no minimum percent effort required for any personnel, but we expect personnel, in particular Principal Investigators (PIs) and Co-investigators, to have efforts that reflect their roles in the project.
Can someone else (assistant, staff, etc.) submit my application for me?Yes, you can add users with administrator access to the proposalCENTRAL application so that someone other than the PI can edit and submit the application.
Can postdoctoral associates apply as PIs?No, postdoctoral associates may not apply. SFARI funds may only be used for personnel considered employees of the grantee institution who are eligible for benefits. Funds may not be used for stipend supplementation unless specifically authorized under the terms of the program from which funds are derived.
Can foreign institutions apply for a grant?Yes, foreign institutions with a 501(c)(3) equivalency may apply.
Can multiple PIs apply for a grant?The applicant organization may designate multiple individuals as PIs who share the authority and responsibility for leading and directing the project, intellectually and logistically. For more information on the responsibilities of PIs, please refer to the personnel definitions in the SFARI glossary below.
Applications with multiple PIs from different institutions that would like to be paid separately must include a signed signature page, budget template and budget justification for each PI. The budget totals for all non-applicant PIs must be included in the “Consortium and Contractual Direct Costs” section and indirect costs for all non-applicant PIs should be included in the “Other Indirect Costs” section.
Does the PI need to sign the signature page?No, only the signing official is required to sign the signature page.
Where do I upload subcontract budget details? There is no space for this under "Consortium and Contractual Costs."Please upload the completed subcontract budget details/budget justification (available for download in the “Proposal Attachments” section) in the “Proposal Attachments” section of the full application on proposalCENTRAL.
Can I make changes to the application once it has been submitted?You must contact the Simons Foundation to unsubmit your full application before you can edit attachments or HTML sections. Please email [email protected] or call 646-654-0066 if you would like to unsubmit your application prior to the 8 March 2013 deadline.
Is validating my proposal the same as submitting it?No. “Validating” the proposal checks for errors and omissions and will alert you to missing requirements of your application. If the application is complete, you must then click on “Submit.” You will receive an email within ten minutes, and should contact [email protected] if you do not receive confirmation and do not see your application in the “Submitted” tab or with the status changed to “Submitted.”
The deadline for notification has passed. What is the status of my proposal?You should receive notification within 24 hours of the deadline. Please check your spam filter settings if you have not received it by then.
Can PIs and Co-investigators submit multiple applications?Yes, both PIs and Co-investigators can submit multiple applications
If I apply for this award, am I eligible for an additional award type?Please contact the Science Team at [email protected] if you would like to apply for multiple award types.
Genetic basis of phenotypic variability in 16p11.2 deletion or duplication
- Awarded: 2013
- Award Type: Targeted: Analysis of Simons VIP Biospecimens
- Award #: 294112
- Evan E. Eichler, Ph.D. University of Washington