Altered somatosensory processing in autism spectrum disorders: Mechanisms and emerging therapeutic opportunities

  • Autism Research
Speaker David Ginty, Ph.D.
Harvard University
Date & Time


Location

Gerald D. Fischbach Auditorium
160 5th Avenue
New York, NY 10010 United States

Tea 4:15 – 5:00 pm
Lecture 5:00 – 6:15 pm

Autism Research

Autism Research lectures bring together scientists and scholars to discuss diverse and important topics related to autism. The lectures are open to the public and are held at the Gerald D. Fischbach Auditorium at the Simons Foundation headquarters in New York City. Tea is served prior to each lecture.

On April 24, 2019, David Ginty presented his work on the neurobiological basis of touch over-reactivity in mouse models of autism spectrum disorders (ASD). He also discussed new pharmacological approaches aimed at reducing sensory over-reactivity and potentially improving cognitive and behavioral abnormalities associated with ASD.

His talk was part of the Simons Foundation Autism Research lecture series.

About the Lecture

Mounting evidence indicates that sensory processing impairments are a key feature of ASD. In this lecture, David Ginty described work that employs molecular genetics, electrophysiological, synaptic and behavioral analyses to define the neurobiological basis of touch over-reactivity in mouse models of ASD, and its relationship to brain development and ASD-associated behavior. He also discussed new pharmacological approaches to treat touch over-reactivity with the goal of reducing sensory over-reactivity and potentially improving cognitive and behavioral abnormalities associated with ASD.

About the Speaker

David Ginty is the Edward R. and Anne G. Lefler Professor of Neurobiology at Harvard Medical School and an investigator of the Howard Hughes Medical Institute. His research focuses on development and functional organization of neural circuits that underlie touch perception in normal and disease states, and he serves as associate director of Harvard’s Program in Neuroscience. Ginty is an elected member of the National Academy of Sciences and the American Academy of Arts and Sciences.

Past Lectures

Phenotyping sleep

Emmanuel Mignot, M.D., Ph.D.Craig Reynolds Professor of Sleep Medicine, Stanford University

On September 16, 2020, Emmanuel Mignot discussed sleep biology as well as sleep disorders and their impact. He presented a link to what is known on the genetics of sleep and sleep disorders. He emphasized the need for large scale objective sleep recording studies with genomic and proteomic analysis to better understand the molecular pathways regulating sleep and circadian biology.

Progress in understanding the genetic basis of mental health

Benjamin Neale, Ph.D.Associate Professor, Analytic and Translational Genetics Unit, Massachusetts General Hospital
Associate Professor in Medicine, Harvard Medical School
Associated Researcher, Broad Institute

On May 6, 2020, Benjamin Neale discussed progress in mapping genetic risk factors for autism, schizophrenia and bipolar disorder.

Autism, autisms, or neurodevelopmental disorders?

Jason Lerch, Ph.D.Director of Preclinical Imaging, Wellcome Centre for Integrative Neuroimaging, University of Oxford
Adjunct Scientist, Mouse Imaging Centre, The Hospital for Sick Children
Associate Professor in Medical Biophysics, University of Toronto

On January 29, 2020, Jason Lerch explored this question: What do modern ways of looking at brains and genes tell us about autism – or autisms – and its relation to attention deficit disorder, obsessive-compulsive disorder and other related disorders of brain development?

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