SFARI 2018 Pilot and Research awardees announced
SFARI is pleased to announce that it intends to fund 36 grants (15 Pilot Awards and 21 Research Awards) in response to the 2018 Pilot and Research Awards request for…
Tag: mouse models
SFARI spring 2018 science meeting discussed latest developments in autism research
SFARI held its thirteenth science meeting April 8–12, 2018. SFARI investigators, collaborators and foundation staff came together to discuss recent findings in autism genetics, molecular and system-level mechanisms, and clinical…
The role of the PTCHD1-antisense long noncoding RNA in autism
Stephen Scherer will study the effects of mutations in the PTCHD1-AS long noncoding RNA gene, a candidate ASD risk gene, using induced pluripotent stem cells and mouse models. Results from…
Exploring deficits in lineage-dependent neocortical circuit assembly in a mouse model of fragile X syndrome
Using a battery of cutting-edge approaches, Song-Hai Shi will investigate lineage-dependent, precise, local and long-range cortical neuron circuit assembly in the Fmr1 knockout mouse model of fragile X syndrome.
Assessing roles for autism-linked epigenetic factors in activity-dependent synapse elimination
Sensory experience and learning refine circuits through elimination of excitatory synapses, a process that depends on activity-driven transcription control and that is deficient in humans with ASD and mouse ASD…
Neurophysiological impact of abnormal sleep during infancy in 16p11.2 deletion mice
Mark Blumberg will perform behavioral and neurophysiological assessments in 16p11.2 deletion mice to determine whether the early sensorimotor and sleep disturbances observed in autism have a common link.