Tag: mouse models

Development of a single-cell mouse cortical gene expression pattern resource that identifies putative brain disorder subtypes Mark Zylka and colleagues generated single-cell RNA-seq data from wild-type mouse cortex during early development and demonstrated how such a resource can be used to identify putative brain disorder subtypes…

SFARI fall 2018 science meeting highlighted recent findings in autism research SFARI held its fourteenth science meeting September 30–October 2, 2018. SFARI investigators, collaborators and foundation staff came together to discuss recent findings in autism genetics, molecular and system-level mechanisms, as…

SFARI Gene: New data release New data were recently added to SFARI Gene. This data release included updated gene scores for candidate autism risk genes, as well as the addition of new genes and copy…

SFARI presentations at INSAR 2019 SFARI Investigators and SFARI science staff will be giving a number of oral presentations at the International Society for Autism Research (INSAR) 2019 Annual Meeting in Montreal, Canada (May 1-4).

Altered somatosensory processing in autism spectrum disorders: Mechanisms and emerging therapeutic opportunities

Augmentation of serotonergic signaling during development in a mouse model of autism: A mechanism to regulate choroid plexus function? Disrupted cerebrospinal fluid (CSF) volume and composition, as well as ventricle formation, are common to many neurodevelopmental disorders, including ASD. Alterations in serotonergic signaling have also been implicated in ASD,…