Altered somatosensory processing in autism spectrum disorders: Mechanisms and emerging therapeutic opportunities
Tag: mouse models
Augmentation of serotonergic signaling during development in a mouse model of autism: A mechanism to regulate choroid plexus function? Disrupted cerebrospinal fluid (CSF) volume and composition, as well as ventricle formation, are common to many neurodevelopmental disorders, including ASD. Alterations in serotonergic signaling have also been implicated in ASD,…
Coordinating animal- and human-based research on sensory alterations in autism spectrum disorders On September 25, 2018, SFARI convened a workshop with the aims of discussing current research on sensory processing in autism and bringing together investigators that conduct animal- and human-based studies…
Enhancement of neurexin-1 function in a genetic mouse model: A novel approach to restore synaptic pathways disrupted in autism Genetic studies of ASD implicate alterations in synaptic development and signaling, with the synaptic protein neurexin-1 playing a pivotal role. Ann Marie Craig aims to develop new approaches to overcome…
Alterations in neuronal excitability are compensatory changes, not causal effects, in autism Dan Feldman and colleagues analyzed four mouse models of autism and found that alterations in the excitation-inhibition ratio may serve as a homeostatic mechanism to prevent network hyperexcitability.
SFARI Winter 2019 Pilot awardees announced SFARI is pleased to announce that it intends to fund 15 grants in response to the Winter 2019 Pilot Award request for applications (RFA).