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Rethinking autism and animal models: A systems perspective
On November 28, 2018, André Fenton discussed work with mouse genetic models of fragile X syndrome (FXS) – the most common single-gene cause of autism spectrum disorder (ASD) symptoms – and focused on the utility of such models to evaluate hypotheses for understanding ASD. He evaluated distinct hypotheses by assessing synapse function and the action potential discharge of knowledge-expressing hippocampus “place cells” during behaviors that require varying cognitive effort.
SFARI Society for Neuroscience 2018 Social
Join the SFARI science team and leaders in the autism research community for an informal evening of food, drink, conversation and mingling on 5 November 2018 in San Diego.
Thinking differently about neurodevelopmental disorders and autism: Lumping vs. splitting
Senior Clinician Scientist, Holland Bloorview Kids Rehabilitation Hospital
Professor, Department of Pediatrics, University of Toronto
On September 26, 2018, Evdokia Anagnostou discussed the challenge of rethinking classification systems and diagnostic labels for autism and related neurodevelopmental disorders in light of recent findings from research and clinical studies.
Autism genetics: Where have we been and where are we going?
On April 10, 2018, Matthew State reviewed the progress that has been made in autism genetics over the past 10 years and the role that the Simons Simplex Collection (SSC) played in this (r)evolution. He also addressed the potential contribution of ongoing genomic studies including whole-genome sequencing as well as the challenges and opportunities of leveraging the genetic findings to identify pathophysiological mechanisms.
On the road to precision health: Brain-based biomarkers in autism spectrum disorder
Professor of Neurology and Pediatrics, Keck School of Medicine, University of Southern California
On 7 February 2018, Shafali Spurling Jeste provided a topical overview of the current state of research in autism biomarkers. She shared data from studies of autism biomarkers in three key areas: early risk prediction (studies of high-risk infants), heterogeneity within the autism spectrum and genetically defined subgroups within autism. Finally, she discussed the challenges around clinical trial design and development and considered how more objective measures of brain function can improve clinical trials.
Arousal, emotion regulation and challenging behaviors: Insights from the Autism Inpatient Collection
Chief of Clinical Enterprise, Boston Children’s Hospital
On 24 January 2018, Matthew Siegel drew upon a new resource, the Autism Inpatient Collection data set, to offer preliminary insights into the relationships between physiologic arousal, emotion dysregulation and the occurrence of challenging behaviors. Such behaviors may represent an attempt to modulate physiologic arousal in minimally verbal individuals with autism spectrum disorders.
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