Rethinking autism and animal models: A systems perspective

  • Autism Research
Speaker André Fenton, Ph.D.
New York University
Date & Time


Location

Gerald D. Fischbach Auditorium
160 5th Avenue
New York, NY 10010 United States

Tea: 4:15 – 5:00pm
Lecture: 5:00 – 6:15pm

Autism Research

Autism Research lectures bring together scientists and scholars to discuss diverse and important topics related to autism.

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On November 28, 2018, André Fenton discussed work with mouse genetic models of fragile X syndrome (FXS) – the most common single-gene cause of autism spectrum disorder (ASD) symptoms – and focused on the utility of such models to evaluate hypotheses for understanding ASD. He evaluated distinct hypotheses by assessing synapse function and the action potential discharge of knowledge-expressing hippocampus “place cells” during behaviors that require varying cognitive effort.

His talk was part of the Simons Foundation Autism Research lecture series.

About the Lecture

We have been amassing important knowledge about the fundamental genetic and molecular bases of ASD and related intellectual disability, but how close are we to understanding how molecular differences cause ASD symptoms? Animal models and a systems approach can help close this gap in understanding and identify strategies to target outcomes rather than causes.

In this lecture, André Fenton discussed work with mouse genetic models of FXS –the most common single-gene cause of ASD symptoms – and focused on the utility of such models to evaluate hypotheses for understanding ASD. He evaluated distinct hypotheses by assessing synapse function and the action potential discharge of knowledge-expressing hippocampus “place cells” during behaviors that require varying cognitive effort. Despite abnormalities in synaptic function within the hippocampus, FXS-mimicking mutations do not disrupt the functioning of individual hippocampal neurons; rather those mutations lead to the discoordination of when those neurons interact. These observations offer novel explanations for inflexibilities in expression of knowledge, learning deficits and inflexible behavior and suggest novel therapeutic strategies that should be evaluated. Such therapeutic strategies are aimed at improving function without directly targeting the molecular foundations of FXS.

About the Speaker

André Fenton is a professor of neural science at New York University. His research focuses on molecular, neural, behavioral and computational aspects of memory. He studies how brains store experiences as memories and how the expression of knowledge activates information that is relevant without activating what is irrelevant. His lab recordings of electrical brain activity are elucidating the physiology of cognitive control and cognitive dysfunction in schizophrenia, intellectual disability and autism. In an effort to integrate investigations and understanding across levels of biological organization, the Fenton lab uses genetic, molecular, electrophysiological, imaging, behavioral, engineering and theoretical methods to investigate these fundamental and interrelated issues in neuroscience.

Fenton and colleagues identified PKMzeta as the first molecule that maintains the persistence of memories in the brain, a discovery recognized by Science Magazine as one of the 10 most important breakthroughs in all of science and technology published in 2006. Fenton founded Bio-Signal Group Corp., which developed and commercialized an FDA-approved portable, wireless and easy-to-use platform for obtaining medical quality electroencephalograms (EEGs) anywhere, anytime and for everyone. It is being used in innovative clinical applications including emergency medicine, sports, space exploration and underserved clinics in Africa. Fenton also co-hosts NOVA Wonderson PBS.

Past Lectures

Rare variants and the genetics of autism

Evan E. Eichler, Ph.D.Professor, Department of Genome Sciences and Howard Hughes Medical Institute, University of Washington, Seattle

Evan Eichler discussed his research on the genetics of autism and related neurodevelopmental conditions.

Phenotyping sleep

Emmanuel Mignot, M.D., Ph.D.Craig Reynolds Professor of Sleep Medicine, Stanford University

Emmanuel Mignot discussed sleep biology as well as sleep disorders and their impact. He presented a link to what is known on the genetics of sleep and sleep disorders. He emphasized the need for large scale objective sleep recording studies with genomic and proteomic analysis to better understand the molecular pathways regulating sleep and circadian biology.

Progress in understanding the genetic basis of mental health

Benjamin Neale, Ph.D.Associate Professor, Analytic and Translational Genetics Unit, Massachusetts General Hospital
Associate Professor in Medicine, Harvard Medical School
Associated Researcher, Broad Institute

Benjamin Neale discussed progress in mapping genetic risk factors for autism, schizophrenia and bipolar disorder.

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