Arousal, emotion regulation and challenging behaviors: Insights from the Autism Inpatient Collection

  • Autism Research
Speaker Matthew Siegel, M.D.
Tufts University
Date & Time


Location

Gerald D. Fischbach Auditorium
160 5th Avenue
New York, NY 10010 United States

Autism Research

Autism Research lectures bring together scientists and scholars to discuss diverse and important topics related to autism. The lectures are open to the public and are held at the Gerald D. Fischbach Auditorium at the Simons Foundation headquarters in New York City. Tea is served prior to each lecture.

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On 24 January 2018, Matthew Siegel drew upon a new resource, the Autism Inpatient Collection data set, to offer preliminary insights into the relationships between physiologic arousal, emotion dysregulation and the occurrence of challenging behaviors. Such behaviors may represent an attempt to modulate physiologic arousal in minimally verbal individuals with autism spectrum disorders.

His talk was part of the Simons Foundation Autism Research lecture series.

About the Lecture

Emotional and behavioral dysregulation are the primary characteristics youth with autism present in clinical settings and are highly predictive of caregiver stress. But the mechanisms that underlie these phenomena are not well understood. These challenges are compounded for youth who are minimally verbal or have an intellectual disability.

In this lecture, Matthew Siegel drew upon a new resource, the Autism Inpatient Collection data set, to offer preliminary insights into the relationships between physiologic arousal, emotion dysregulation and the occurrence of challenging behaviors. Such behaviors may represent an attempt to modulate physiologic arousal in minimally verbal individuals with autism spectrum disorders (ASD). Siegel presented pilot data, using machine learning approaches, that identify physiologic arousal as a biomarker of distress in ASD and that illustrate an opportunity to predict the onset of challenging behavior in real time. This work seeks to address the critical, parent-identified issue of uncertainty regarding when a challenging behavior may occur and may open new avenues for intervention.

About the Speaker

Matthew Siegel is an associate professor of psychiatry and pediatrics at Tufts University School of Medicine, the vice president for medical affairs, developmental disorders service at Maine Behavioral Healthcare, and a faculty scientist at the Maine Medical Center Research Institute.  He attended Amherst College, Stanford Medical School and trained at Brown University in child psychiatry, psychiatry, and pediatrics. Siegel is the principal investigator of the Autism Inpatient Collection and is an expert in the inpatient treatment of challenging behaviors in individuals with autism and other developmental disorders.

Past Lectures

Phenotyping sleep

Emmanuel Mignot, M.D., Ph.D.Craig Reynolds Professor of Sleep Medicine, Stanford University

On September 16, 2020, Emmanuel Mignot discussed sleep biology as well as sleep disorders and their impact. He presented a link to what is known on the genetics of sleep and sleep disorders. He emphasized the need for large scale objective sleep recording studies with genomic and proteomic analysis to better understand the molecular pathways regulating sleep and circadian biology.

Progress in understanding the genetic basis of mental health

Benjamin Neale, Ph.D.Associate Professor, Analytic and Translational Genetics Unit, Massachusetts General Hospital
Associate Professor in Medicine, Harvard Medical School
Associated Researcher, Broad Institute

On May 6, 2020, Benjamin Neale discussed progress in mapping genetic risk factors for autism, schizophrenia and bipolar disorder.

Autism, autisms, or neurodevelopmental disorders?

Jason Lerch, Ph.D.Director of Preclinical Imaging, Wellcome Centre for Integrative Neuroimaging, University of Oxford
Adjunct Scientist, Mouse Imaging Centre, The Hospital for Sick Children
Associate Professor in Medical Biophysics, University of Toronto

On January 29, 2020, Jason Lerch explored this question: What do modern ways of looking at brains and genes tell us about autism – or autisms – and its relation to attention deficit disorder, obsessive-compulsive disorder and other related disorders of brain development?

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