Arousal, emotion regulation and challenging behaviors: Insights from the Autism Inpatient Collection

  • Autism Research
Speaker Matthew Siegel, M.D.
Tufts University
Date & Time


Location

Gerald D. Fischbach Auditorium
160 5th Avenue
New York, NY 10010 United States

Autism Research

Autism Research lectures bring together scientists and scholars to discuss diverse and important topics related to autism. The lectures are open to the public and are held at the Gerald D. Fischbach Auditorium at the Simons Foundation headquarters in New York City. Tea is served prior to each lecture.

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On 24 January 2018, Matthew Siegel drew upon a new resource, the Autism Inpatient Collection data set, to offer preliminary insights into the relationships between physiologic arousal, emotion dysregulation and the occurrence of challenging behaviors. Such behaviors may represent an attempt to modulate physiologic arousal in minimally verbal individuals with autism spectrum disorders.

His talk was part of the Simons Foundation Autism Research lecture series.

About the Lecture

Emotional and behavioral dysregulation are the primary characteristics youth with autism present in clinical settings and are highly predictive of caregiver stress. But the mechanisms that underlie these phenomena are not well understood. These challenges are compounded for youth who are minimally verbal or have an intellectual disability.

In this lecture, Matthew Siegel drew upon a new resource, the Autism Inpatient Collection data set, to offer preliminary insights into the relationships between physiologic arousal, emotion dysregulation and the occurrence of challenging behaviors. Such behaviors may represent an attempt to modulate physiologic arousal in minimally verbal individuals with autism spectrum disorders (ASD). Siegel presented pilot data, using machine learning approaches, that identify physiologic arousal as a biomarker of distress in ASD and that illustrate an opportunity to predict the onset of challenging behavior in real time. This work seeks to address the critical, parent-identified issue of uncertainty regarding when a challenging behavior may occur and may open new avenues for intervention.

About the Speaker

Matthew Siegel is an associate professor of psychiatry and pediatrics at Tufts University School of Medicine, the vice president for medical affairs, developmental disorders service at Maine Behavioral Healthcare, and a faculty scientist at the Maine Medical Center Research Institute.  He attended Amherst College, Stanford Medical School and trained at Brown University in child psychiatry, psychiatry, and pediatrics. Siegel is the principal investigator of the Autism Inpatient Collection and is an expert in the inpatient treatment of challenging behaviors in individuals with autism and other developmental disorders.

Past Lectures

Altered somatosensory processing in autism spectrum disorders: Mechanisms and emerging therapeutic opportunities

David Ginty, Ph.D.Professor of Neurobiology, Harvard University

On April 24, 2019, David Ginty presented his work on the neurobiological basis of touch over-reactivity in mouse models of autism spectrum disorder (ASD). He also discussed new pharmacological approaches aimed at reducing sensory over-reactivity and potentially improving cognitive and behavioral abnormalities associated with ASD.

Mapping human cerebral cortex: Structure, function, connectivity, development and evolution

David Van Essen, Ph.D.Alumni Endowed Professor, Washington University in St. Louis

On April 3, 2019, David Van Essen provided an overview of basic principles of cortical organization and connectivity from studies of laboratory animals and analyses of individual variability in humans. He also highlighted a new map (‘parcellation’) of the human cerebral cortex based on data from the Human Connectome Project.

The genetic influences on autism spectrum disorder risk

Elise Robinson, Sc.D.Assistant Professor, Harvard T.H. Chan School of Public Health
Associate Member, Broad Institute

On January 30, 2019, Elise Robinson provided an overview of the role that genetic factors play in autism spectrum disorders and discussed the next steps to further understand autism genetics.

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