From genotype to phenotype in autism: The role of adaptive physiology in flies and mice

  • Autism Research
Speaker Graeme Davis, Ph.D.
University of California, San Francisco
Date & Time


Location

Gerald D. Fischbach Auditorium
160 5th Avenue
New York, NY 10010 United States

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Tea 4:15 – 5:00 pm
Lecture 5:00 pm – 6:15 pm

Autism Research

Autism Research lectures bring together scientists and scholars to discuss diverse and important topics related to autism. The lectures are open to the public and are held at the Gerald D. Fischbach Auditorium at the Simons Foundation headquarters in New York City. Tea is served prior to each lecture.

On November 20, 2019, Graeme Davis will present his research investigating the mechanisms that lie at the interface between neuronal homeostatic plasticity and ASD genetics.

His talk is part of the Simons Foundation Autism Research lecture series.

About the Lecture

The identification of rare de novo mutations that confer high risk for autism spectrum disorders (ASD) has generated tremendous new molecular insight and progress. Yet, in cases where a known mutation confers risk, additional processes contribute to the phenotypic severity of ASD. Homeostatic plasticity has garnered considerable attention as an adaptive process of neurons that might be relevant and contribute to the spectrum of ASD severity in the human population. But virtually nothing is known at a mechanistic level regarding the interface of homeostatic plasticity and ASD genetics. Furthermore, there remains ongoing debate whether homeostatic plasticity is normally induced or whether it is impaired by gene mutations that confer risk for ASD.

In this lecture, Graeme Davis will describe a novel, unexpected genetic architecture that connects mutations in ASD-associated genes with the mechanisms of homeostatic plasticity in both invertebrate and mammalian nervous systems. He will present a novel means by which a diversity of ASD-associated risk genes may converge to disrupt homeostatic plasticity, thereby compromising the robustness of synaptic transmission. This information may be relevant to developing new therapeutic approaches that might someday alleviate ASD symptoms, regardless of the underlying genetic mutation(s) that confer risk for ASD.

About the Speaker

Graeme Davis received his B.A. at Williams College in 1989 and a Ph.D. from the University of Massachusetts in 1994. He pursued a postdoctoral fellowship at the University of California, Berkeley, under the guidance of Corey S. Goodman. In 1998, he began his independent academic career as an assistant professor at the University of California, San Francisco (UCSF) School of Medicine. Davis has remained at UCSF his entire career and is currently the Morris Hertzstein Distinguished Professor of Medicine and the former chairman of the department of biochemistry and biophysics.

He and his laboratory have pioneered the field of homeostatic plasticity, beginning with work published in the mid-1990s and continuing to this day. They have taken advantage of genome-scale forward genetics screens in model organisms to define a majority of genes currently known to control the homeostatic regulation of neurotransmitter release and ion channel gene expression. Recently, the Davis lab has turned its attention to the interface of homeostatic plasticity and the mechanisms of neurological and psychiatric disease.

Past Lectures

Altered somatosensory processing in autism spectrum disorders: Mechanisms and emerging therapeutic opportunities

David Ginty, Ph.D.Professor of Neurobiology, Harvard University

On April 24, 2019, David Ginty presented his work on the neurobiological basis of touch over-reactivity in mouse models of autism spectrum disorder (ASD). He also discussed new pharmacological approaches aimed at reducing sensory over-reactivity and potentially improving cognitive and behavioral abnormalities associated with ASD.

Mapping human cerebral cortex: Structure, function, connectivity, development and evolution

David Van Essen, Ph.D.Alumni Endowed Professor, Washington University in St. Louis

On April 3, 2019, David Van Essen provided an overview of basic principles of cortical organization and connectivity from studies of laboratory animals and analyses of individual variability in humans. He also highlighted a new map (‘parcellation’) of the human cerebral cortex based on data from the Human Connectome Project.

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