SFARI is pleased to announce that it intends to fund 36 grants (15 Pilot Awards and 21 Research Awards) in response to the 2018 Pilot and Research Awards request for applications.
Sung Eun “Samuel” Kwon plans to use a recently developed optical reporter of ERK activity, combined with a neuronal activity reporter, to monitor the dynamics of ERK signaling and neuronal activity in awake-behaving SynGAP mutant mice.
SFARI is pleased to announce that it has awarded 27 grants (21 Pilot Awards and 6 Research Awards) in response to the 2016 Pilot and Research Awards request for applications.
It is well established that homeostatic signaling systems interface with the mechanisms of developmental and learning-related plasticity to achieve stable yet flexible neural function and animal behavior. Experimental evidence from organisms as diverse as Drosophila, mice and humans demonstrates that homeostatic signaling systems stabilize neural function through the modulation of synaptic transmission, ion channel abundance and neurotransmitter receptor trafficking. At a fundamental level, if homeostatic plasticity is compromised, then the nervous system will be less robust to perturbation. As such, it is widely speculated that defective or maladaptive homeostatic plasticity will be relevant to the cause or severity of autism. However, clear molecular or genetic links between autism and homeostatic plasticity have yet to be defined in any organism.
SFARI is pleased to announce that it has awarded 28 grants (15 Pilot Awards and 13 Research Awards) in response to the 2015 Pilot and Research Awards request for applications.
A common feature of mouse models of autism spectrum disorders (ASDs) is an imbalance between excitation and inhibition within circuits of the central nervous system. This imbalance is thought to contribute to disrupted neural function in these disorders, but the ultimate cause of this imbalance remains unclear.