Nenad Sestan, M.D., Ph.D.

Professor, Yale University

SFARI Investigator Website

Nenad Sestan is the Harvey and Kate Cushing Professor of Neuroscience, a professor of comparative medicine, genetics and psychiatry, and a member of the Kavli Institute for Neuroscience at Yale School of Medicine. He obtained his M.D. from the University of Zagreb and his Ph.D. in neurobiology from Yale University.

Sestan’s laboratory investigates how neural circuits form within the developing cerebral cortex. He also studies how neural circuits were modified during human evolution and may become compromised in neurodevelopmental and psychiatric disorders. Most recently, his laboratory discovered that the large mammalian (porcine) brain is more resilient to a lack of oxygen than previously thought. It also described a first-in-class technology that can restore brain perfusion and reverse some of the effects of oxygen deprivation.

Sestan is the recipient of several international honors and awards, including the Constance Lieber Prize, Krieg Cortical Discoverer Prize, NARSAD (National Alliance for Research on Schizophrenia and Depression) Distinguished Investigator (awarded by the Brain & Behavior Research Foundation), McDonnell Scholar and Krieg Cortical Scholar. He is also a member of the National Academy of Medicine, Croatian Academy of Sciences and Arts and Connecticut Academy of Science and Engineering. He has been a member of the BrainSpan, BRAIN Initiative Cell Census Network and PsychENCODE consortia and has been featured in Nature’s “10 People Who Mattered in Science in 2019.”

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Funded Projects

SFARI Funded Publications

A novel SMARCC1-mutant BAFopathy implicates epigenetic dysregulation of neural progenitors in hydrocephalus. Singh A.K., Viviano S., Allington G., McGee S., Kiziltug E., Mekbib K.Y., Shohfi J.P., Duy P.Q., Tyrone DeSpenza J., Furey C.G., Reeves B.C., Smith H., Ma S., Sousa A. M. M., Cherskov A., Allocco A., Nelson-Williams C., Haider S., Rizvi S.R.A., Alper S., Sestan N., Shimelis H., Walsh L.K., Lifton R.P., Moreno-De-Luca A., Jin S.C., Kruszka P., Deniz E., Kahle K.
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