Tag: CUL3

July 24, 2019

A pipeline for functional assessment of autism-associated missense mutations in C. elegans

December 01, 2017

In vitro modeling of genetic subtypes of autism

January 20, 2017

SFARI Gene: New data release

Normal human chromosomes visualized by spectral karyotyping (SKY). Spectral karyotyping is a molecular cytogenetic technique used to simultaneously visualize all the pairs of chromosomes in an organism in different colors. Fluorescently labeled probes for each chromosome are made by labeling chromosome-specific DNA with different fluorophores. Because there are a limited number of spectrally distinct fluorophores, a combinatorial labeling method is used to generate many different colors. Spectral differences generated by combinatorial labeling are captured and analyzed by using an interferometer attached to a fluorescence microscope. Image processing software then assigns a pseudo color to each spectrally different combination, allowing the visualization of the individually colored chromosomes. This technique is used to identify structural chromosome aberrations in cancer cells and other disease conditions when Giemsa banding or other techniques are not accurate enough.

December 01, 2016

Identification of shared transcriptional profiles with three high-confidence autism mouse models

September 01, 2015

Translational dysregulation of the RhoA pathway in autism

July 01, 2014

Role of the CUL3-mediated ubiquitination pathway in autism

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