Ivan Iossifov, Ph.D.

Professor, Cold Spring Harbor Laboratory

SFARI Investigator Website

Ivan Iossifov is an associate professor at Cold Spring Harbor Laboratory and a core faculty member at the New York Genome Center (NYGC). He obtained a master’s degree in computer science from Sofia University in Bulgaria and a Ph.D. in biomedical informatics from Columbia University.

Iossifov’s research interests are in the areas of genomics and systems biology and their application to the study of neuropsychiatric disorders like autism, schizophrenia and cancer. At the NYGC, Iossifov’s research focuses on large autism-sequencing projects. He is facilitating collaborations with groups both within the NYGC and outside the NYGC that study other common human diseases.

Funded Projects

Framework for genetic variants in phenotype-rich family collections

Awarded: 2015
Award Type: Research

SFARI Funded Publications

The Genotype and Phenotypes in Families (GPF) platform manages the large and complex data at SFARI. Chorbadjiev L., Cokol M., Weinstein Z., Shi K., Fleisch C., Dimitrov N., Mladenov S., Xu S., Hall J., Ford S., Lee Y.-h., Yamrom B., Marks S., Munoz A., Lash A., Volfovsky N., Iossifov I.

Heterozygous deletion of the autism-associated gene CHD8 impairs synaptic function through widespread changes in gene expression and chromatin compaction. Shi X., Lu C., Corman A., Nikish A., Zhou Y., Platt R. J., Iossifov I., Zhang F., Pan J.Q., Sanjana N.

Genetic control of mRNA splicing as a potential mechanism for incomplete penetrance of rare coding variants. Einson J., Glinos D., Boerwinkle E., Castaldi P., Darbar D., de Andrade M., Ellinor P., Fornage M., Gabriel S., Germer S., Gibbs R., Hersh C.P., Johnsen J., Pstay B., Vasan R.S., Rich S.S., Rienstra M., Rotter J.I., Saferali A., Shoemaker M.B., Silverman E., Smith A.V., NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium, Mohammadi P., Castel S.E., Iossifov I., Lappalainen T.