Ivan Iossifov, Ph.D.

Associate Professor, Cold Spring Harbor Laboratory

SFARI Investigator Website

Ivan Iossifov is an associate professor at Cold Spring Harbor Laboratory and a core faculty member at the New York Genome Center (NYGC). He obtained a master’s degree in computer science from Sofia University in Bulgaria and a Ph.D. in biomedical informatics from Columbia University.

Iossifov’s research interests are in the areas of genomics and systems biology and their application to the study of neuropsychiatric disorders like autism, schizophrenia and cancer. At the NYGC, Iossifov’s research focuses on large autism-sequencing projects. He is facilitating collaborations with groups both within the NYGC and outside the NYGC that study other common human diseases.

Funded Projects

Framework for genetic variants in phenotype-rich family collections

Awarded: 2015
Award Type: Research

SFARI Funded Publications

Rates of contributory de novo mutation in high and low-risk autism families. Yoon S., Munoz A., Yamrom B., Lee Y.-h., Andrews P., Marks S., Wang Z., Reeves C., Winterkorn L., Krieger A., Buja A., Pradhan K., Ronemus M., Baldwin K.K., Levy D., Wigler M., Iossifov I.

Research Highlight

N-terminal variant Asp14Asn of the human p70 S6 Kinase 1 enhances translational signaling causing different effects in developing and mature neuronal cells. Venkatasubramani J.P., Subramanyam P., Pal R., Reddy B.K., Srinivasan D.J., Chattarji S., Iossifov I., Klann E., Bhattacharya A.

Modified penetrance of coding variants by cis-regulatory variation contributes to disease risk. Castel S.E., Cervera A., Mohammadi P., Aguet F., Reverter F., Wolman A., Guigo R., Iossifov I., Vasileva A., Lappalainen T.