CHD8 regulates gut epithelial cell function and affects autism-related behaviours through the gut-brain axis.
Molecular Mechanisms
Proximity labeling identifies a repertoire of site-specific R-loop modulators.
Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing.
Single-cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells.
Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids.
Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s.
Macrophages on the margin: Choroid plexus immune responses.
A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex.
Altered inflammatory response in FMRP-deficient microglia.
Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity.
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