Oestrogen engages brain MC4R signalling to drive physical activity in female mice.
Molecular Mechanisms
Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of genetic variants in vivo.
Gestationally-dependent immune organization at the maternal-fetal interface.
Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.
The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating sonic hedgehog signalling.
Full-length isoform transcriptome of the developing human brain provides further insights into autism.
Randomized crossover feasibility trial of helminthic Trichuris suis ova versus placebo for repetitive behaviors in adult autism spectrum disorder.
Regulation and reversibility of DNA methylation changes associated with autism spectrum disorders
DNA methylation is a key epigenetic modification that is disrupted in a subset of ASD cases. In the current project, Hume Stroud aims to assess regulatory mechanisms affecting the activity of the DNA cystine methyltransferase DNMT3A and whether there is a critical window during which DNMT3A function can be restored in mouse models.
A unified resource and configurable model of the synapse proteome and its role in disease.
Overexpression of CD47 is associated with brain overgrowth and 16p11.2 deletion syndrome.
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