A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex.
Molecular Mechanisms
Altered inflammatory response in FMRP-deficient microglia.
Postmitotic accumulation of histone variant H3.3 in new cortical neurons establishes neuronal chromatin, transcriptome, and identity.
Virally encoded connectivity transgenic overlay RNA sequencing (VECTORseq) defines projection neurons involved in sensorimotor integration.
Single-cell epigenomics reveals mechanisms of human cortical development.
PTEN mutations in autism spectrum disorder and congenital hydrocephalus: Developmental pleiotropy and therapeutic targets.
Regulation of prefrontal patterning and connectivity by retinoic acid.
Regulation of cortical interneuron wiring in neurodevelopmental disorders
Deficits in feedforward inhibition mediated by parvalbumin-expressing (PV+) cortical interneurons are common among animal models of autism. In the current project, Oscar Marín and Beatriz Rico plan to investigate molecular mechanisms regulating the formation of excitatory synapses onto PV+ interneurons. Specifically, they will focus their studies on the ErbB4-Tsc2-mTOR signaling pathway. Findings from these studies will provide insights into the development of an important pool of synaptic connections of relevance for autism.
Human microglia states are conserved across experimental models and regulate neural stem cell responses in chimeric organoids.
Cortical organoids model early brain development disrupted by 16p11.2 copy number variants in autism.
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