Molecular Mechanisms

Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model.

Cortical interneurons in autism.

Wide spectrum of neuronal and network phenotypes in human stem cell-derived excitatory neurons with Rett syndrome-associated MECP2 mutations.

CHD8 regulates gut epithelial cell function and affects autism-related behaviours through the gut-brain axis.

Proximity labeling identifies a repertoire of site-specific R-loop modulators.

Full-length transcript sequencing of human and mouse cerebral cortex identifies widespread isoform diversity and alternative splicing.

Single-cell transcriptome identifies molecular subtype of autism spectrum disorder impacted by de novo loss-of-function variants regulating glial cells.

Effects of early geometric confinement on the transcriptomic profile of human cerebral organoids.

Biophysical Kv3 channel alterations dampen excitability of cortical PV interneurons and contribute to network hyperexcitability in early Alzheimer’s.

Macrophages on the margin: Choroid plexus immune responses.

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