SFARI | Topic: Molecular Mechanisms

Mutations in 51 RNA-binding proteins have been strongly implicated in autism spectrum disorder (ASD). Howard Lipshitz aims to develop experimental resources for the study of these proteins in neuronal development, provide genome-wide information on the dynamics of mRNA regulation during neuronal differentiation and identify the target RNAs of eight high-priority ASD-associated RNA-binding proteins, thus predicting the molecular functions of these proteins.

Multi-omic analysis along the gut-brain axis points to a functional architecture of autism.

Is there an association between prenatal testosterone and autistic traits in adolescents?

Pax6 limits the competence of developing cerebral cortical cells.

Autism risk gene POGZ promotes chromatin accessibility and expression of clustered synaptic genes.

16pdel lipid changes in iPSC-derived neurons and function of FAM57B in lipid metabolism and synaptogenesis.

Memo1-mediated tiling of radial glial cells facilitates cerebral cortical development.

SCEPTRE improves calibration and sensitivity in single-cell CRISPR screen analysis.

ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research.