Joseph Gleeson, M.D.

Professor, University of California, San Diego

SFARI Investigator, SFARI Scientific Review Board Website

Joseph Gleeson is the Rady Professor at University of California, San Diego, School of Medicine and Rady Children’s Hospital Genomics Institute. He has been a Simons Foundation Autism Research Initiative Investigator since 2008. He is an investigator with the Howard Hughes Medical Institute, an elected member of the National Academy of Medicine and the 2017 recipient of the inaugural Constance Lieber Prize for Innovation in Developmental Neuroscience. His laboratory is focused on understanding the genetic, molecular and cellular basis of pediatric brain disease, including autism, epilepsy and intellectual disability.

Gleeson’s lab has identified many new causes for disease through recruitment and targeted sequencing of patient cohorts from special populations including groups with elevated rates of parental consanguinity. The lab has focused on potentially treatable disorders including forms of autism that can be treated with dietary supplements or treatments for forms of severe epilepsy. Gleeson’s team is excited to find potentially treatable conditions in children with brain disease and hopes that research can help in developing treatments for what were previously considered untreatable conditions.

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Funded Projects

SFARI Funded Publications

Paternally inherited cis-regulatory structural variants are associated with autism. Brandler W.M., Antaki D., Gujral M., Kleiber M.L., Whitney J., Maile M.S., Hong O., Chapman T.R., Tan S., Tandon P., Pang T., Tang S.C., Vaux K.K., Yang Y., Harrington E., Juul S., Turner D.J., Thiruvahindrapuram B., Kaur G., Wang Z., Kingsmore S.F., Gleeson J., Bisson D., Kakaradov B., Telenti A., Venter J.C., Corominas R., Toma C., Cormand B., Rueda I., Guijarro S., Messer K.S., Nievergelt C.M., Arranz M.J., Courchesne E., Pierce K., Muotri A., Iakoucheva L., Hervas A., Scherer S. W., Corsello C., Sebat J.
Biallelic variants in KIF14 cause intellectual disability with microcephaly. Makrythanasis P., Maroofian R., Stray-Pedersen A., Musaev D., Zaki M.S., Mahmoud I.G., Selim L., Elbadawy A., Jhangiani S.N., Coban Akdemir Z.H., Gambin T., Sorte H.S., Heiberg A., McEvoy-Venneri J., James K.N., Stanley V., Belandres D., Guipponi M., Santoni F.A., Ahangari N., Tara F., Doosti M., Iwaszkiewicz J., Zoete V., Backe P.H., Hamamy H., Gleeson J., Lupski J., Karimiani E.G., Antonarakis S.E.
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