Ellen Hoffman studied biochemistry at the State University of New York (SUNY) at Stony Brook and received her M.D. from SUNY Stony Brook School of Medicine. As a medical student, she worked in the laboratory of Gail Mandel, an Investigator of the Howard Hughes Medical Institute. Hoffman did her residency in psychiatry and fellowship in child and adolescent psychiatry at the Icahn School of Medicine at Mount Sinai, where she worked in the laboratories of Deanna Benson and Joseph Buxbaum. She then completed a research fellowship in childhood-onset neuropsychiatric disorders at the Yale Child Study Center and received her Ph.D. in investigative medicine from Yale University in the laboratories of Matthew State and Antonio Giraldez. She is currently an assistant professor in the Yale Child Study Center and the Yale Neurogenetics Program.
The Hoffman laboratory conducts translational research aimed at understanding the biological mechanisms underlying autism spectrum disorders and discovering new pharmacological treatments. Hoffman’s research focuses on investigating the function of genes that are strongly associated with autism to determine how disruption of these genes alters brain development and the neural circuits underlying simple behaviors. The long-term goal of her research is to use this gene-based approach to identify relevant biological pathways and novel pharmacological treatments that target these pathways. She also works clinically as a child psychiatrist and as an attending physician, supervising Yale University child psychiatry fellows.