Tag: social impairments

Alterations in cellular pH gradients cause defects in neuronal communication and autism-related behaviors in mice lacking NHE9

Using a mouse lacking brain-localized NHE9, Edwards shows that pH gradients affect neuronal communication and autism-like behaviors.

Gating of social reward by oxytocin in the ventral tegmental area

Robert Malenka and colleagues find that oxytocin acts within the ventral tegmental area to increase dopamine reward neurons to reinforce the rewarding aspects of social interactions in mice.

Identification of an amygdala circuit involved in social learning

Amiel Rosenkranz and colleagues have identified a specific intra-amygdala circuit, from the lateral nucleus to the medial nucleus, which is critical for social learning.

SFARI 2016 Explorer awardees announced

SFARI is pleased to announce that it has awarded 14 grants over the past year in response to the Explorer Awards request for applications.

CASPR2 antibodies from human maternal serum mediate autism-like phenotypes in mice

Betty Diamond reports on a method to isolate monoclonal brain-reactive antibodies from plasma obtained from mothers in the SSC, showing their in utero exposure can cause ASD.

DIXDC1 contributes to neurodevelopmental and psychiatric phenotypes via altered Wnt signaling

Benjamin Cheyette finds higher rates of DIXDCI disruptions in individuals with ASD, schizophrenia or bipolar, and DIXDC1 signaling rescue improves mouse ASD-like behaviors.