Neville Sanjana is a core faculty member at the New York Genome Center (NYGC) and an assistant professor of biology, and neuroscience and physiology at New York University (NYU) and NYU’s Grossman School of Medicine. He received his Ph.D. from the Massachusetts Institute of Technology in 2010 and worked as a postdoctoral fellow of the Simons Center for the Social Brain at the Broad Institute with Feng Zhang, joining NYGC and NYU as a faculty member in 2016.
Research in the Sanjana laboratory is focused on developing technologies for massively parallel forward genetic screens and genome engineering and using these tools to interrogate how specific genetic variants influence disease risk. The laboratory pursues this goal by combining complementary approaches from bioengineering, genomics, neuroscience, cancer biology and systems biology.
The laboratory has developed technologies for high-throughput genome editing and functional genomic screens, including genome-wide screens in vitro and in vivo and scanning mutagenesis to identify functional elements in the noncoding genome. Recently, Sanjana’s team has developed methods for coupling CRISPR perturbations to single-cell chromatin accessibility, called CRISPR-sciATAC (Liscovitch-Brauer et al., Nat. Biotechnol., 2021) and for integrating gene editing with single-cell transcriptomics and proteomics to connect mutations in noncoding regions to target genes, called STING-seq (Morris et al., bioRxiv, 2021).