The genetic influences on autism spectrum disorder risk

  • Autism Research
Speaker Elise Robinson, Sc.D.
Harvard T.H. Chan School of Public Health
Date & Time


Location

Gerald D. Fischbach Auditorium
160 5th Avenue
New York, NY 10010 United States

Tea: 4:15 – 5:00pm
Lecture: 5:00 – 6:15pm

Autism Research

Autism Research lectures bring together scientists and scholars to discuss diverse and important topics related to autism.

On January 30, 2019, Elise Robinson provided an overview of the role that genetic factors play in autism spectrum disorders and discussed the next steps to further understand autism genetics.

Her talk was part of the Simons Foundation Autism Research lecture series.

About the lecture

For decades, scientists have known that genetic factors contribute to autism spectrum disorders (ASDs). Ongoing research is identifying the genes responsible, and recent studies have produced an unprecedented volume of genetic associations to ASDs.

In this lecture, Elise Robinson provided an overview of these findings. She discussed both rare and common genetic risk factors. She also outlined challenges to the interpretation of these findings as well as the next steps in understanding the role genetics plays in autism.

About the Speaker

Elise Robinson is an assistant professor of epidemiology at the Harvard T.H. Chan School of Public Health and an associate member of the Broad Institute of MIT and Harvard. She is also an affiliated faculty member with the Analytic and Translational Genetics Unit at Massachusetts General Hospital.

Robinson’s research focuses on the genetic epidemiology of behavior and cognition. She is interested in using genetic data to understand the biology of neurodevelopmental variation and to study differences within and between neuropsychiatric disorders. She received a Sc.D. in psychiatric epidemiology from the Harvard T.H. Chan School of Public Health and completed postdoctoral training at Massachusetts General Hospital and the Broad Institute.

Past Lectures

How emotions shape our memories

Kelsey C. Martin, M.D., Ph.D.Executive Vice President, Autism and Neuroscience
Leonard Mlodinow, Ph.D.Physicist and Author

Have you ever contemplated the difference between a feeling, a thought and a memory? And how do all these things fit together in making us who we are?

Leonard Mlodinow is a theoretical physicist and best-selling author. In his latest book, “Emotional: How Feelings Shape Our Thinking,” he unpacks the role emotions play in our thinking and mental well-being.

Kelsey Martin, director of the Simons Foundation Autism Research Initiative (SFARI) and the foundation’s neuroscience collaborations, has spent much of her career as a neuroscientist seeking to understand better how experiences change brain connectivity to store long-term memories.

What do we mean by ‘autism risk genes’?

David Ledbetter, Ph.D.
Chief Clinical Officer, Dascena

Joseph Buxbaum, Ph.D.
Director, Seaver Autism Center
Professor, Psychiatry, Neuroscience, Genetics and Genomic Sciences
Vice Chair for Research and Vice Chair for Mentoring, Psychiatry, Icahn School of Medicine at Mount Sinai

Heather Mefford, M.D., Ph.D.
Full Member, St. Jude Children’s Research Hospital

David Ledbetter and Joseph Buxbaum discussed whether there are genes for which mutations confer risk specific to autism or whether these genes are really conferring general risk of disrupted brain development. The discussion was moderated by Heather Mefford.

Small molecules, genes and antisense oligonucleotides: Industry perspectives on treatment development for ASD

Federico Bolognani, M.D., Ph.D.
Vice President, Head of Clinical Science, Axial Therapeutics

Stuart Cobb, Ph.D.
Chief Scientific Officer, Neurogene; Research Fellow, University of Edinburgh

Yael Weiss, M.D., Ph.D.
Vice President, Business Development, Ultragenyx

Randy Carpenter, M.D.
Chief Medical Officer, Rett Syndrome Research Trust; Co-Founder, Allos Pharma

Federico Bolognani, Stuart Cobb, and Yael Weiss joined a panel to discuss new industry developments on the use of small molecules, gene therapy and antisense oligonucleotides as treatment approaches for autism spectrum disorders (ASD). The panel discussion was moderated by Randall Carpenter.

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