A joint project of the Foundation for Angelman Syndrome Therapeutics (FAST) and SFARI, the International Angelman Syndrome Research Council (INSYNC-AS) held its inaugural meeting on July 9, 2021.
Ivan Iossifov, Michael Wigler and colleagues provided a detailed comparison of simplex and multiplex families with autism, supporting the view that de novo mutations are a more frequent cause of autism in low- than in high-risk families.
This issue of the SFARI newsletter includes: (1) 2022 Human Cognitive and Behavioral Science — Request for applications, (2) Autism BrainNet: whole-genome sequencing data now available, (3) SFARI announces recipients of SPARK Research Match DEI initiative, (4) SFARI hosts workshop on newborn screening, (5) Highlights of SFARI-funded research, (6) 2022 Pilot Award — Request for applications, (7) Bridge to Independence Award — Request for applications, (8) SFARI Supplement to Enhance Equity and Diversity (SEED) — Request for applications, (9) SPARK Research Match Diversity, Equity and Inclusivity — Request for applications.
On September 27, 2021, SFARI convened a one-day virtual workshop to explore and discuss opportunities and risks for early detection of neurodevelopmental disorders through genomic sequencing.
Whole-genome sequencing data from more than 50 brains in the Autism BrainNet collection are now available for research purposes. Additional data will be released in the coming months.
Anna Penn and colleagues showed that loss of the supply of the hormone allopregnanolone (ALLO) from the placenta leads to cerebellar brain and behavioral deficits in male offspring.
SFARI Investigators Lilia Iakoucheva and Alysson Muotri and colleagues utilized 3D organoid brain cultures to demonstrate how defects in neuron migration are affected in 16p11.2 deletion and duplication conditions.
SFARI Investigator Bruce Herring and colleagues showed that ASD-linked mutations in Trio and NLGN1 cause deficits in synapse development and function.
SFARI 2022 Human Cognitive and Behavioral Science request for applications (RFA) is now open. Grants awarded through this RFA are intended to produce foundational knowledge about the neurobehavioral differences associated with autism spectrum disorder.
This issue of the SFARI newsletter includes: (1) 2022 Pilot Award — Request for applications, (2) Updates to SFARI's 2022 requests for grant applications, (3) SFARI 2021 Director Awards announced, (4) More than funding: Career development opportunities abound for Bridge to Independence fellows, (5) Simons Searchlight: December 2021 data release, (6) SPARK December 2021 update: New phenotypic and genomic data available, (7) SFARI hosts virtual fall 2021 science meeting, (8) Simons Searchlight CSNK2A1, HIVEP2, MED13L and SETBP1 Family and Scientific Conference, (9) Highlights of SFARI-funded research, (10) Bridge to Independence Award — Request for applications, (11) SFARI Supplement to Enhance Equity and Diversity (SEED) — Request for applications, (12) SPARK Research Match Diversity, Equity and Inclusivity — Request for applications.