A SFARI channel now exists on bioRxiv, one of the most used preprint servers for biology. This channel should help readers to find preprints reporting SFARI-funded research findings more quickly as well as encouraging more SFARI investigators to post preprints ahead of publication.
Updated medical, developmental and educational outcomes information on a subset of families who participated in the Simons Simplex Collection (SSC) — a total of 440 families — is now available to approved researchers via SFARI Base. Researchers may also apply via SFARI Base to re-contact this subset of families for additional research studies.
Presentations that will be given by SFARI Investigators at the 2017 International Meeting for Autism Research (IMFAR) in San Francisco (May 10-13) are highlighted.
New data were added to SFARI Gene in March 2017. This data release included updated gene scores for candidate autism risk genes, new animal models, and new copy number variant loci associated with autism.
Christopher Gregg and colleagues demonstrate that diverse epigenetic mechanisms affect allele-specific gene expression in the mammalian brain.
SFARI Investigator Liqun Luo discusses the neurodevelopmental disorder Smith-Magenis syndrome and his lab’s efforts to understand its underlying biology.
As an organization dedicated to the advancement of scientific knowledge, the Simons Foundation stands united with the scientists and institutions we support in their opposition to the recently announced executive order on visas and immigration to the United States from seven Middle Eastern countries.
Kevin Bender and Stephan Sanders show that ASD-associated SCN2A variants lead to impaired NaV1.2 channel activity and reduced neuronal excitability.
Amiel Rosenkranz and colleagues have identified a specific intra-amygdala circuit, from the lateral nucleus to the medial nucleus, which is critical for social learning.
Lauren Weiss and colleagues used a reverse pathway genetic approach, focused on the RAS/MAPK pathway, to show that gene-gene interactions contribute to autism.