Molecular Mechanisms

Age-related sperm DNA methylation changes are transmitted to offspring and associated with abnormal behavior and dysregulated gene expression.

Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis.

Synaptic basis of social dysfunction: A focus on postsynaptic proteins linking group-I mGluRs with AMPARs and NMDARs.

Loss of WDFY3 in mice alters cerebral cortical neurogenesis reflecting aspects of the autism pathology.

Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming.

Transcriptome analysis reveals dysregulation of innate immune response genes and neuronal activity-dependent genes in autism.

The developmental switch in GABA polarity is delayed in fragile X mice.

Snx14 regulates neuronal excitability, promotes synaptic transmission, and is imprinted in the brain of mice.

Environmental enrichment modulates 5-hydroxymethylcytosine dynamics in hippocampus.

A highly conserved program of neuronal microexons is misregulated in autistic brains.

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