Molecular Mechanisms

Inhibition of p21-activated kinase rescues symptoms of fragile X syndrome in mice.

Ten_m3 regulates eye-specific patterning in the mammalian visual pathway and is required for binocular vision.

A neuroligin-3 mutation implicated in autism increases inhibitory synaptic transmission in mice.

Phosphodiesterase 1B differentially modulates the effects of methamphetamine on locomotor activity and spatial learning through DARPP32-dependent pathways: evidence from PDE1B-DARPP32 double-knockout mice.

Fragile X: translation in action.

MeCP2, a key contributor to neurological disease, activates and represses transcription.

Role for metabotropic glutamate receptor 5 ( mGluR5 ) in the pathogenesis of fragile X syndrome.

Application of a translational profiling approach for the comparative analysis of CNS cell types.

FGF acts as a co-transmitter through adenosine A(2A) receptor to regulate synaptic plasticity.

A translational profiling approach for the molecular characterization of CNS cell types.

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