Molecular Mechanisms

Hierarchical cortical transcriptome disorganization in autism.

Epidemiological and serological investigation into the role of gestational maternal influenza virus infection and autism spectrum disorders.

Shank is a dose-dependent regulator of Ca_v1 calcium current and CREB target expression.

MeCP2-regulated miRNAs control early human neurogenesis through differential effects on ERK and AKT signaling.

Pathogenic variants that alter protein code often disrupt splicing.

Opposing effects on Na_v1.2 function underlie differences between SCN2A variants observed in individuals with autism spectrum disorder or infantile seizures.

The autism-linked UBE3A^T485A mutant E3 ubiquitin ligase activates the Wnt/beta-catenin pathway by inhibiting the proteasome.

Structures of neuroligin-1 and the neuroligin-1/neurexin-1 beta complex reveal specific protein-protein and protein-Ca2+ interactions.

Mice lacking the signaling molecule CalDAG-GEFI represent a model for leukocyte adhesion deficiency type III.

Correction of fragile X syndrome in mice.

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