Altered synaptic transmission and maturation of hippocampal CA1 neurons in a mouse model of human chr16p11.2 microdeletion.
Molecular Mechanisms
T-lymphocytes and cytotoxic astrocyte blebs correlate across autism brains.
Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans.
Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology.
Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions.
Engineering of human brain organoids with a functional vascular-like system.
MeCP2: An epigenetic regulator of critical periods.
A GluN2B mutation identified in autism prevents NMDA receptor trafficking and interferes with dendrite growth.
Identification and manipulation of splicing variants that contribute to autism
About 15 percent of individuals with autism have an identifiable gene-disrupting mutation that contributes strongly to their symptoms. Some of these gene-disrupting mutations act by changing how the mRNA is spliced prior to making a protein. In this project, Stephan Sanders aims to apply recent advances in the detection of these splicing mutations to autism sequencing data, validate the splicing disruption independently and assess whether antisense oligonucleotides can restore typical gene function.
Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.
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