SFARI | Topic: Molecular Mechanisms

Developmental barcoding and lineage mapping of the brain in neurotypical mice and mouse models of autism

The ability to create a detailed map of brain development across embryogenesis is important in understanding its alterations in neurodevelopmental disorders such as autism. Reza Kalhor will establish developmental barcoding technologies to map lineage trees of neurons during embryogenesis and compare them in neurotypical and autism genetic mouse models to better understand the etiology of autism.

The immune signaling adaptor LAT contributes to the neuroanatomical phenotype of 16p11.2 BP2-BP3 CNVs.

Altered synaptic transmission and maturation of hippocampal CA1 neurons in a mouse model of human chr16p11.2 microdeletion.

T-lymphocytes and cytotoxic astrocyte blebs correlate across autism brains.

Viral manipulation of functionally distinct interneurons in mice, non-human primates and humans.

Impaired regulation of KCC2 phosphorylation leads to neuronal network dysfunction and neurodevelopmental pathology.

Kctd13-deficient mice display short-term memory impairment and sex-dependent genetic interactions.

Engineering of human brain organoids with a functional vascular-like system.

MeCP2: An epigenetic regulator of critical periods.

A GluN2B mutation identified in autism prevents NMDA receptor trafficking and interferes with dendrite growth.