Engineering of human brain organoids with a functional vascular-like system.
Molecular Mechanisms
MeCP2: An epigenetic regulator of critical periods.
A GluN2B mutation identified in autism prevents NMDA receptor trafficking and interferes with dendrite growth.
Identification and manipulation of splicing variants that contribute to autism
About 15 percent of individuals with autism have an identifiable gene-disrupting mutation that contributes strongly to their symptoms. Some of these gene-disrupting mutations act by changing how the mRNA is spliced prior to making a protein. In this project, Stephan Sanders aims to apply recent advances in the detection of these splicing mutations to autism sequencing data, validate the splicing disruption independently and assess whether antisense oligonucleotides can restore typical gene function.
Mania- and anxiety-like behavior and impaired maternal care in female diacylglycerol kinase eta and iota double knockout mice.
FMRP modulates neural differentiation through m6A-dependent mRNA nuclear export.
FMRP binding to a ranked subset of long genes is revealed by coupled CLIP and TRAP in specific neuronal cell types.
Prenatal treatment path for Angelman syndrome and other neurodevelopmental disorders.
Differential NOVA2-mediated splicing in excitatory and inhibitory neurons regulates cortical development and cerebellar function.
Widespread alterations in translation elongation in the brain of juvenile Fmr1 knockout mice.
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