Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.
Molecular Mechanisms
The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating sonic hedgehog signalling.
Full-length isoform transcriptome of the developing human brain provides further insights into autism.
Randomized crossover feasibility trial of helminthic Trichuris suis ova versus placebo for repetitive behaviors in adult autism spectrum disorder.
Regulation and reversibility of DNA methylation changes associated with autism spectrum disorders
DNA methylation is a key epigenetic modification that is disrupted in a subset of ASD cases. In the current project, Hume Stroud aims to assess regulatory mechanisms affecting the activity of the DNA cystine methyltransferase DNMT3A and whether there is a critical window during which DNMT3A function can be restored in mouse models.
A unified resource and configurable model of the synapse proteome and its role in disease.
Overexpression of CD47 is associated with brain overgrowth and 16p11.2 deletion syndrome.
Genotype and defects in microtubule-based motility correlate with clinical severity in KIF1A-associated neurological disorder.
Generation of fate patterns via intercellular forces.
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation.
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