Full-length isoform transcriptome of the developing human brain provides further insights into autism.
Molecular Mechanisms
Randomized crossover feasibility trial of helminthic Trichuris suis ova versus placebo for repetitive behaviors in adult autism spectrum disorder.
Regulation and reversibility of DNA methylation changes associated with autism spectrum disorders
DNA methylation is a key epigenetic modification that is disrupted in a subset of ASD cases. In the current project, Hume Stroud aims to assess regulatory mechanisms affecting the activity of the DNA cystine methyltransferase DNMT3A and whether there is a critical window during which DNMT3A function can be restored in mouse models.
A unified resource and configurable model of the synapse proteome and its role in disease.
Overexpression of CD47 is associated with brain overgrowth and 16p11.2 deletion syndrome.
Genotype and defects in microtubule-based motility correlate with clinical severity in KIF1A-associated neurological disorder.
Generation of fate patterns via intercellular forces.
CaMKII activation persistently segregates postsynaptic proteins via liquid phase separation.
Integrating barcoded neuroanatomy with spatial transcriptional profiling enables identification of gene correlates of projections.
Brain gene co-expression networks link complement signaling with convergent synaptic pathology in schizophrenia.
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