Molecular Mechanisms

Cellular and behavioral effects of altered NaV1.2 sodium channel ion permeability in Scn2aK1422E mice.

FMRP regulates mRNAs encoding distinct functions in the cell body and dendrites of CA1 pyramidal neurons.

Probing the VIPR2 microduplication linkage to schizophrenia in animal and cellular models.

Maternal steroid levels and the autistic traits of the mother and infant.

Transcriptional-regulatory convergence across functional mdd risk variants identified by massively parallel reporter assays.

Oestrogen engages brain MC4R signalling to drive physical activity in female mice.

Cre-dependent massively parallel reporter assay allows for cell-type specific assessment of the functional effects of genetic variants in vivo.

Gestationally-dependent immune organization at the maternal-fetal interface.

Novel epigenetic clock for fetal brain development predicts prenatal age for cellular stem cell models and derived neurons.

The ciliary gene INPP5E confers dorsal telencephalic identity to human cortical organoids by negatively regulating sonic hedgehog signalling.

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