Dan Feldman is a neuroscientist who studies the function and plasticity of neural circuits in cerebral cortex, using the rodent whisker somatosensory cortex (S1) as a model system. This model has powerful experimental advantages, which allow cortical function to be studied at cellular, circuit, systems and behavioral levels, and allow sensitive measurements of circuit dysfunction in rodent disease models. Past work in his lab has focused on sensory coding, tactile sensory behavior, synaptic and circuit physiology, and how sensory experience regulates circuit development including excitation-inhibition balance. Experimental approaches include quantitative behavior, multisite neurophysiological recordings, 2-photon calcium imaging of neuronal population activity in vivo, synaptic physiology and optogenetics. Feldman’s lab is now beginning to study cortical circuit dysfunction in transgenic mouse models of syndromic and non-syndromic autism.