Tag: interneurons

Single-nucleus RNA sequencing identifies brain cell types with significant changes in gene expression in autism Using single-nucleus RNA sequencing of postmortem cortical tissue from individuals with ASD, Arnold Kriegstein and colleagues identify upper-layer excitatory neurons and microglia as key cell types affected in ASD.

Parvalbumin down-regulation as a common pathophysiological mechanism in autism spectrum disorders Studies in individuals with autism and in autism mouse models suggest that alterations in parvalbumin expression in interneurons may represent a unifying molecular hub for autism pathobiology. By manipulating parvalbumin…

FENS Forum 2018: Presentations by SFARI Investigators SFARI Investigators will be giving a number of presentations at the 11th FENS Forum of Neuroscience in Berlin, Germany (July 7-11).

SFARI 2016 Explorer awardees announced SFARI is pleased to announce that it has awarded 14 grants over the past year in response to the Explorer Awards request for applications.

Dissecting inhibitory microcircuits during learning in a mouse model of Dravet syndrome Autism spectrum disorders (ASDs) encompass a number of disorders that are typified by communication deficits, reduced behavioral flexibility, poor socialization, learning disabilities and a tendency toward repetitive behaviors. While the…

SFARI 2016 Pilot and Research awardees announced SFARI is pleased to announce that it has awarded 27 grants (21 Pilot Awards and 6 Research Awards) in response to the 2016 Pilot and Research Awards request for applications.