SFARI is pleased to announce that it intends to fund 36 grants (15 Pilot Awards and 21 Research Awards) in response to the 2018 Pilot and Research Awards request for applications.
SFARI held its thirteenth science meeting April 8–12, 2018. SFARI investigators, collaborators and foundation staff came together to discuss recent findings in autism genetics, molecular and system-level mechanisms, and clinical studies. In addition to keynote and session presentations, two panels convened investigators to discuss the current state of autism genetics research and the biology of SCN2A, a high-confidence autism risk gene.
Caroline Robertson’s laboratory aims to develop a neurophysiological marker of autism that reflects reductions in GABAergic action in the autistic brain. Such a marker will help shed light on the neurobiology of autism and aid in the development of pharmacological interventions.
Grants awarded through this RFA are intended to advance our understanding of the genetic basis of autism. Investigators who are interested in analyzing genomic data in innovative ways from thousands of SPARK families are encouraged to apply.
Available data will include whole-exome and genome-wide genotyping data from approximately 4,500 individuals with autism spectrum disorder (ASD) and their biological parents. Approximately half of these families will also have genomic data from an unaffected sibling. In addition, whole-genome sequencing data will be available from approximately 400 other ASD individuals, plus their biological parents and unaffected siblings. A limited phenotypic dataset for all participants will be available.
We expect to fund several awards in the range of $100,000 (direct costs) for 18 months. Higher budgets will be considered, but we expect such budgets to be strongly justified.
Chaste will use genomic prediction to assess the relationship between genetic risk for ASD and autistic traits in the general population.