SFARI is pleased to announce that it intends to fund 36 grants (15 Pilot Awards and 21 Research Awards) in response to the 2018 Pilot and Research Awards request for applications.
Sensory experience and learning refine circuits through elimination of excitatory synapses, a process that depends on activity-driven transcription control and that is deficient in humans with ASD and mouse ASD models. Kimberly Huber and Tae-Kyung Kim will determine the role of ASD-linked epigenetic factors in activity-driven synapse elimination using mouse model systems and identify their gene regulatory networks at the single neuron level.
Gabel will utilize mouse models to explore how ASD-associated mutations in DNMT3A alter DNA methylation in the brain and drive ASD pathology.
Christopher Gregg and colleagues demonstrate that diverse epigenetic mechanisms affect allele-specific gene expression in the mammalian brain.
Presentations that will be given by SFARI Investigators at Neuroscience 2016 in San Diego (November 12-16) are highlighted.
Single-nucleotide polymorphism genotyping and whole-exome and whole-genome sequencing studies have been key for the identification of genetic loci and mutations underlying autism spectrum disorder (ASD) susceptibility. Although none of the risk genes identified so far contribute to more than 1 percent of ASD cases, overall the search for ASD treatments can profoundly benefit from the study of rare and syndromic forms of ASDs.