Tag: 16p11.2

Biased spatiotemporal dynamics of striatal circuits impact behavior in autism

The molecular and circuit underpinnings of repetitive behavior dysfunction — a core symptom of ASD — have remained elusive, but it is assumed that they rely on the same basal ganglia circuits that underlie repetitive behavior control and habit formation. The current project aims to investigate, with unprecedented spatial and temporal resolution, the circuit alterations in the striatum that lead to alterations in spontaneous and learned behavioral sequences in ASD.

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