SFARI | Search Results for “syngap1”

Photo of a A neurodivergent teenage girl (with autism and Rett syndrome) wearing bright headphones and smiling while sitting next to her personal care assistant at home.

Using the Linear References from the Pangenome to Discover Missing Autism Variants

Image of the hippocampus was taken with an ultra-widefield high-speed multiphoton laser microscope.

2025 Autism Rat Consortium Meeting Held in New York City

On September 29, 2025, the SFARI Autism Rat Consortium (ARC) held its annual meeting in the Usher Institute of the University of Edinburgh. This year’s event brought together ARC PIs and trainees who specialize in the use of rat models.

SFARI Funds 5 Projects Aiming to Understand Early Neural Circuit Development in Autism

SFARI is pleased to announce it will fund five projects investigating the influence of autism-associated risk genes on early neurodevelopment and links to later circuit-level functional outcomes. These awards will provide up to $3.6 million over 4 years to each team of researchers.

Two parents of children with the MED13L genetic mutation at a conference hosted by Simons Searchlight.

Simons Searchlight December 2023 Update: New Phenotypic Data Available

New phenotypic data from Simons Searchlight participants were recently added to SFARI Base. This release includes data from individuals with 94 gene changes and 15 copy number variants known to be connected to autism.

January 2023 update: New Simons Searchlight data added to SFARI Base

New Simons Searchlight data were recently added to SFARI Base. The data released included phenotypic data from individuals with 16p11.2 copy number variant (CNVs), 1q21.1 CNVs, 7q11.23 duplication and variants in 32 single genes associated with autism and related neurodevelopmental conditions.

New DYRK1A and GRIN2B zebrafish models added to SFARI resources

New zebrafish lines with mutations in the high-confidence autism risk genes DYRK1A and GRIN2B have been added to SFARI resources.

Simons Searchlight: July 2022 data release

New phenotypic data from Simons Searchlight participants were recently added to SFARI Base. This release includes data from individuals with 59 gene changes and nine copy number variants known to be connected to autism.

SFARI workshop explores mitochondrial dysfunction in autism

On March 25 and 28, 2022 SFARI hosted a workshop to explore the role of mitochondria in ASD risk. The workshop brought together experts in mitochondrial research spanning cellular, molecular, genetic, clinical and pharmacological areas and provided points for discussion on how to move this research forward.

Simons Searchlight: December 2021 data release

New Simons Searchlight data were recently added to SFARI Base. This data release included phenotypic data from individuals with 16p11.2 copy number variants (CNVs), 1q21.1 CNVs, 7q11.23 duplication and variants in 32 single genes associated with autism and related neurodevelopmental conditions.

New zebrafish lines added to SFARI resources

Zebrafish lines for autism risk genes DYNC1H1 and MEF2C have been recently added to SFARI resources to study autism spectrum disorder.