In collaboration with the Nancy Lurie Marks Family Foundation (NLMFF), SFARI has funded the generation and maintenance of more than 200 iPS cell lines from individuals with either a genetic finding linked to autism or a related neurodevelopmental disorder. Donors are participants in the SFARI supported human cohorts Simons Simplex Collection (SSC) and Simons Searchlight. All iPS cell lines are available for distribution to approved researchers as part of the SFARI resources that can be requested through SFARI Base.

iPSCs from individuals in our human cohorts are especially valuable because of the detailed clinical and genetic characterization available for many of the participants. These data can also be requested through SFARI Base along with the iPS cell lines.

A list of datasets available via SFARI Base can be found here.

A list of iPSCs available for request can be found here.

The majority of iPSCs available have been created by the JAX-NYSCF collaborative or Sampled. The iPSC inventory linked above summarizes source cell type and reprogramming method for all available iPSC lines. For detailed QC measures, please contact the SFARI Data and Biospecimen Repository (SDBR) team at [email protected].

Prices are available here.

To submit an order for iPSC lines or to request phenotypic or genetic data linked to individual iPSC lines, please create an account with SFARI Base and follow the steps outlined in the system.

If you have any questions about your SFARI Base account, creating a request, or our resources, please email [email protected].

All iPSC lines are stored at the SFARI biorepository at Sampled. Once iPSCs have been ordered via SFARI Base, Sampled will coordinate shipping and provide protocols for thawing and growing the iPSC lines.

Creation of the iPSC lines listed in Table 1 was co-funded by the Nancy Lurie Marks Family Foundation (NLMFF).